| Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans. | |
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MedLine Citation:
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PMID: 8731519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tolerance of the behavioral effects of the short-acting, endogenous hallucinogen, N,N-dimethyltryptamine (DMT) is seen inconsistently in animals, and has not been produced in humans. The nature and time course of responses to repetitive, closely spaced administrations of an hallucinogenic dose of DMT were characterized. Thirteen experienced hallucinogen users received intravenous 0.3 mg/kg DMT fumarate, or saline placebo, four times, at 30 min intervals, on 2 separate days, in a randomized, double-blind, design. Tolerance to "psychedelic" subjective effects did not occur according to either clinical interview or Hallucinogen Rating Scale scores. Adrenocorticotropic hormone (ACTH), prolactin, cortisol, and heart rate responses decreased with repeated DMT administration, although blood pressure did not. These data demonstrate the unique properties of DMT relative to other hallucinogens and underscore the differential regulation of the multiple processes mediating the effects of DMT. |
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Authors:
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R J Strassman; C R Qualls; L M Berg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 39 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-10-02 Completed Date: 1996-10-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 784-95 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, School of Medicine, University of New Mexico, Albuquerque, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Adult Arousal / drug effects* Double-Blind Method Drug Tolerance Female Hallucinations / chemically induced, psychology Hallucinogens / pharmacology* Humans Hydrocortisone / blood Male Middle Aged N,N-Dimethyltryptamine / pharmacology* Perception / drug effects Prolactin / blood |
| Grant Support | |
ID/Acronym/Agency:
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R01-DA08096/DA/NIDA NIH HHS; RR00997-15/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hallucinogens; 50-23-7/Hydrocortisone; 61-50-7/N,N-Dimethyltryptamine; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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