Document Detail


Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  16783828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Members of the ezrin-radixin-moesin (ERM) protein family regulate cellular shape, motility, and proliferation and potentially influence ability to metastasize. We investigated the correlation between ERM subcellular localization and survival in patients with squamous cell carcinoma (SCC) METHODS: Tissue microarrays (TMAs) were constructed from paraffin-embedded tissue. TMA sections were evaluated for ERM protein expression immunohistochemically. The results were compared across clinical and histopathologic variables RESULTS: ERM staining results for 47 patients showed that cytoplasmic ERM expression was prevalent in tumors (>92%). Whereas ezrin and moesin also localized to the membrane, only willin was found in the nucleus of tumors. Multivariable Cox regression analysis demonstrated that strong cytoplasmic ezrin expression was independently associated with poorer survival (p = .04, hazard ratio 1.82) CONCLUSIONS: Both level of expression and subcellular localization of ERM proteins may be important indicators of clinical outcome in SCC. This pilot study justifies the need for an expanded validation study of ERM proteins and clinical outcome.
Authors:
Rashna Madan; Margaret Brandwein-Gensler; Nicolas F Schlecht; Kristin Elias; Eleanor Gorbovitsky; Thomas J Belbin; Radma Mahmood; Dwayne Breining; Hong Qian; Geoffrey Childs; Joseph Locker; Richard Smith; Missak Haigentz; Frank Gunn-Moore; Michael B Prystowsky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  28     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-16     Completed Date:  2007-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1018-27     Citation Subset:  IM    
Affiliation:
Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / metabolism*,  mortality,  pathology
Cytoplasm / metabolism
Cytoskeletal Proteins / metabolism*
Female
Humans
Immunohistochemistry
Laryngeal Mucosa / metabolism
Laryngeal Neoplasms / metabolism*,  mortality,  pathology
Male
Membrane Proteins
Microfilament Proteins / metabolism
Middle Aged
Mouth Mucosa / metabolism
Mouth Neoplasms / metabolism*,  mortality,  pathology
Pilot Projects
Prognosis
Survival Analysis
Tissue Array Analysis
Tumor Markers, Biological / metabolism*
Grant Support
ID/Acronym/Agency:
CA103547/CA/NCI NIH HHS; CA104402/CA/NCI NIH HHS; CA115243/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/FRMD6 protein, human; 0/Membrane Proteins; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 0/ezrin; 144131-77-1/moesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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