Document Detail


Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation.
MedLine Citation:
PMID:  18321949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Surplus energy is principally stored in white adipose tissue (WAT) as triacylglycerol and mobilized via lipolysis through norepinephrine (NE) released from sympathetic nervous system terminals innervating WAT. We demonstrated that central melanocortin receptor agonism provokes differential sympathetic drives across WAT pads and interscapular brown adipose tissue (IBAT). Here we tested for differential WAT and IBAT sympathetic drive to known lipolytic stimuli {glucoprivation [2-deoxy-D-glucose (2-DG)], cold exposure (5 degrees C), food deprivation (16 h), or both cold exposure and food deprivation} by measuring NE turnover (NETO). Only inguinal WAT NETO significantly increased across all stimuli. Dorsal subcutaneous WAT NETO only increased with glucoprivation. Retroperitoneal WAT NETO increased with glucoprivation, cold and cold + food deprivation, but not by food deprivation. Epididymal WAT NETO was unaffected by glucoprivation but increased with cold, cold + food deprivation or food deprivation, but to a small significant degree. IBAT NETO was unaffected by glucoprivation or food deprivation, but increased with cold and cold + food deprivation. Plasma glucose decreased with food deprivation and increased with 2-DG administration or cold exposure. Plasma glycerol was increased with food deprivation, cold, and their combination but not with 2-DG, whereas plasma free fatty acids increased with food deprivation, cold + food deprivation, and 2-DG. These data show differential sympathetic drive to WAT and BAT for four different lipolytic stimuli, exemplifying the fat pad-specific pattern of WAT sympathetic drive across lipid-mobilizing conditions and emphasizing the need to analyze multiple adipose depots for measures of NETO and likely most measures.
Authors:
Nilton A Brito; Márcia N Brito; Timothy J Bartness
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-05
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  294     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-06-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1445-52     Citation Subset:  IM    
Affiliation:
Department of Morphophysiological Sciences, State University of Maringá, Maringá, PR Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / innervation*,  physiology
Adipose Tissue, Brown / physiology
Adipose Tissue, White / physiology
Animals
Antimetabolites / pharmacology
Blood Glucose / metabolism
Body Weight / physiology
Cold Temperature / adverse effects*
Cricetinae
Deoxyglucose / pharmacology
Eating / physiology
Energy Metabolism / physiology
Epinephrine / blood
Fatty Acids, Nonesterified / blood
Food Deprivation / physiology*
Glucose / deficiency*
Glycerol / blood
Leptin / blood
Male
Norepinephrine / blood
Phodopus
Sympathetic Nervous System / physiology*
Grant Support
ID/Acronym/Agency:
R01 DK 35254/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antimetabolites; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Leptin; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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