| Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation. | |
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MedLine Citation:
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PMID: 18321949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Surplus energy is principally stored in white adipose tissue (WAT) as triacylglycerol and mobilized via lipolysis through norepinephrine (NE) released from sympathetic nervous system terminals innervating WAT. We demonstrated that central melanocortin receptor agonism provokes differential sympathetic drives across WAT pads and interscapular brown adipose tissue (IBAT). Here we tested for differential WAT and IBAT sympathetic drive to known lipolytic stimuli {glucoprivation [2-deoxy-D-glucose (2-DG)], cold exposure (5 degrees C), food deprivation (16 h), or both cold exposure and food deprivation} by measuring NE turnover (NETO). Only inguinal WAT NETO significantly increased across all stimuli. Dorsal subcutaneous WAT NETO only increased with glucoprivation. Retroperitoneal WAT NETO increased with glucoprivation, cold and cold + food deprivation, but not by food deprivation. Epididymal WAT NETO was unaffected by glucoprivation but increased with cold, cold + food deprivation or food deprivation, but to a small significant degree. IBAT NETO was unaffected by glucoprivation or food deprivation, but increased with cold and cold + food deprivation. Plasma glucose decreased with food deprivation and increased with 2-DG administration or cold exposure. Plasma glycerol was increased with food deprivation, cold, and their combination but not with 2-DG, whereas plasma free fatty acids increased with food deprivation, cold + food deprivation, and 2-DG. These data show differential sympathetic drive to WAT and BAT for four different lipolytic stimuli, exemplifying the fat pad-specific pattern of WAT sympathetic drive across lipid-mobilizing conditions and emphasizing the need to analyze multiple adipose depots for measures of NETO and likely most measures. |
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Authors:
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Nilton A Brito; Márcia N Brito; Timothy J Bartness |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-03-05 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 294 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-06-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1445-52 Citation Subset: IM |
Affiliation:
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Department of Morphophysiological Sciences, State University of Maringá, Maringá, PR Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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innervation*,
physiology Adipose Tissue, Brown / physiology Adipose Tissue, White / physiology Animals Antimetabolites / pharmacology Blood Glucose / metabolism Body Weight / physiology Cold Temperature / adverse effects* Cricetinae Deoxyglucose / pharmacology Eating / physiology Energy Metabolism / physiology Epinephrine / blood Fatty Acids, Nonesterified / blood Food Deprivation / physiology* Glucose / deficiency* Glycerol / blood Leptin / blood Male Norepinephrine / blood Phodopus Sympathetic Nervous System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK 35254/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Leptin; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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