Document Detail

Differential stroke-induced proliferative response of distinct precursor cell subpopulations in the young and aged dentate gyrus.
MedLine Citation:
PMID:  20570606     Owner:  NLM     Status:  MEDLINE    
The capability of the adult brain to generate new hippocampal neurons after brain insults like stroke is decreasing during the aging process. Recent evidence further indicates that the proliferative properties of the precursor cells change in the aged brain. We therefore analyzed the early proliferative response of distinct precursor cell populations in the subgranular zone of the dentate gyrus in 3 and 16 months old transgenic nestin-green-fluorescent protein mice 4 days after ischemic cortical infarcts. A detailed immunocytochemical analysis of proliferating precursors revealed a significant infarct-induced activation of the earliest radial glia-like precursor cells (type 1 cells) and the more differentiated precursor cell subtypes (type 2b cells) in young mice. In contrast the proliferation of early neuronal precursor cells (type 2a cells) was stimulated in the aged brain. Additional long-term experiments further demonstrated that this differential proliferative response of distinct precursor cells is associated with an enhanced number of newborn neurons in the young DG after stroke whereas this increase in neurogenesis was absent in the aged brain. However, our study demonstrates that even precursor cells in the aged hippocampus possess the ability to respond to remote cortical infarcts.
J Walter; S Keiner; O W Witte; C Redecker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-24
Journal Detail:
Title:  Neuroscience     Volume:  169     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1279-86     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Hans-Berger-Clinic for Neurology, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany.
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MeSH Terms
Aging / pathology*
Cell Proliferation
Cell Survival
Cerebral Infarction / pathology
Dentate Gyrus / pathology
Genes, Reporter
Green Fluorescent Proteins / genetics
Intermediate Filament Proteins / genetics
Mice, Transgenic
Nerve Tissue Proteins / genetics
Neural Stem Cells / pathology
Neuroglia / pathology
Neurons / pathology
Stroke / pathology*
Reg. No./Substance:
0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/nestin; 147336-22-9/Green Fluorescent Proteins

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