Document Detail

Differential stimulation of VEGF-C production by adhesion/growth-regulatory galectins and plant lectins in human breast cancer cells.
MedLine Citation:
PMID:  21187459     Owner:  NLM     Status:  In-Process    
MATERIALS AND METHODS: The effects of human galectins and five plant lectins reacting with distinct determinants of N- and O-glycans on the accumulation of VEGF-C in serum-free cell culture media of human breast cancer cells endowed with high (MDA-MB-231) and low (MCF7, T-47D, and SK-BR-3) VEGF-C-producing abilities were examined.
RESULTS: All tested lectins stimulated VEGF-C production by MDA-MB-231 cells, albeit with different potency. Concanavalin A, but not galectins, was also able to stimulate VEGF-C production by low VEGF-C-producing cell lines MCF7 and T-47D. Both VEGF-C mRNA and protein were strongly up-regulated in SK-BR-3 cells by concanavalin A and wheat germ agglutinin, but not jacalin.
CONCLUSION: The differential response of breast cancer cell lines separated by the endogenous level of VEGF-C production suggests that galectins may contribute to tumor-associated lymphangiogenesis in a cell-specific manner.
Alexander V Timoshenko; Herbert Kaltner; Sabine André; Hans-Joachim Gabius; Peeyush K Lala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4829-33     Citation Subset:  IM    
Department of Biology, The University of Western Ontario, 1151 Richmond Street North, London, Ontario N6A 5B7, Canada.
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