Document Detail


Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.
MedLine Citation:
PMID:  23144969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show cognitive decline in terms of a mild cognitive impairment already in early stages that predict the development of dementia, which can occur in up to 80% of PD patients over the long term, called Parkinson's disease dementia (PDD). So far, diagnosis of PD/PDD is made according to clinical and neuropsychological examinations while laboratory data is only used for exclusion of other diseases. The aim of this study was the identification of possible biomarkers in cerebrospinal fluid (CSF) of PD, PDD and controls (CON) which predict the development of dementia in PD. For this, a proteomic approach optimized for CSF was performed using 18 clinically well characterized patients in a first step with subsequent validation using 84 patients. Here, we detected differentially sialylated isoforms of Serpin A1 as marker for differentiation of PD versus PDD in CSF. Performing 2D-immunoblots, all PDD patients could be identified correctly (sensitivity 100%). Ten out of 24 PD patients showed Serpin A1 isoforms in a similar pattern like PDD, indicating a specificity of 58% for the test-procedure. In control samples, no additional isoform was detected. On the basis of these results, we conclude that differentially sialylated products of Serpin A1 are an interesting biomarker to indicate the development of a dementia during the course of PD.
Authors:
Sarah Jesse; Stefan Lehnert; Olaf Jahn; Lucilla Parnetti; Hilkka Soininen; Sanna-Kaisa Herukka; Petra Steinacker; Saskia Tawfik; Hayrettin Tumani; Christine A F von Arnim; Manuela Neumann; Hans A Kretzschmar; Hasan Kulaksiz; Martin Lenter; Jens Wiltfang; Boris Ferger; Bastian Hengerer; Markus Otto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-05-09     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48783     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Ulm, Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / cerebrospinal fluid,  metabolism
Brain / metabolism
Dementia / diagnosis,  etiology,  metabolism*
Humans
Parkinson Disease / complications,  diagnosis,  metabolism*
Protein Isoforms / cerebrospinal fluid,  metabolism
Protein Processing, Post-Translational
Proteomics
Sensitivity and Specificity
alpha 1-Antitrypsin / cerebrospinal fluid,  metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Isoforms; 0/alpha 1-Antitrypsin
Comments/Corrections

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