| Differential sensitivity to central leptin and insulin in male and female rats. | |
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MedLine Citation:
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PMID: 12606509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of fat in the body differs between the male and female sexes and is associated with the relative secretion of the two "adiposity" hormones leptin and insulin. We now report that the brains of male and female rats are differentially sensitive to the catabolic actions of small doses of these two hormones. Leptin (1 or 3.5 microg/2 microl) or saline (2 microl) was administered into the third cerebral ventricle of age- and weight-matched male and female rats. Leptin significantly reduced food intake in female and male rats over 4 h; however, leptin reduced 24-h intake in female but not in male rats. When the same rats were administered insulin (1 or 4 mU/2 microl) or saline (2 microl), male but not female rats had a robust reduction in food intake over 24 h. Previous research demonstrates the melanocortins are a central mediator of the effects of both leptin and insulin. However, we found no sex differences in sensitivity to the melanocortin agonist MTII (0.01, 0.1, 0.3, and 1.0 nmol/2 microl). These results suggest that the sex differences in sensitivity to leptin and insulin at the doses that we injected occur upstream of the melanocortin receptors. Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently. |
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Authors:
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Deborah J Clegg; Christine A Riedy; Kathleen A Blake Smith; Stephen C Benoit; Stephen C Woods |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 52 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-27 Completed Date: 2003-05-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 682-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267-0559, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Composition Body Weight / drug effects Brain / drug effects*, physiology Eating / drug effects Female Injections, Intraventricular Insulin / administration & dosage* Leptin / administration & dosage*, blood Male Rats Rats, Long-Evans Receptors, Corticotropin / physiology Receptors, Melanocortin Sex Characteristics* alpha-MSH / analogs & derivatives*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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DK 17844/DK/NIDDK NIH HHS; DK 54080/DK/NIDDK NIH HHS; DK 56863/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Receptors, Corticotropin; 0/Receptors, Melanocortin; 0/alpha-MSH (4-10)amide, Ac-Nle(4)-cyclo(Asp(5)-Phe(7)-Lys(10))-; 11061-68-0/Insulin; 581-05-5/alpha-MSH |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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