Document Detail


Differential secretion of chemokines from peripheral blood in pregnant compared with non-pregnant women.
MedLine Citation:
PMID:  9350639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The maintenance of a normal pregnancy is dependent on the delicate interaction between the endocrine and the immune systems. Cytokines are thought to play a key role in pregnancy by way of local modulation of the immune system at the level of peripheral leukocytes. This study examined the potential of peripheral venous blood cultures from pregnant women throughout gestation and from non-pregnant women to produce the chemokines monocyte chemotactic protein-1 (MCP-1), interleukin-8 (IL-8) and RANTES. Significantly (P = < 0.001), higher levels of MCP-1 were released from peripheral blood cultures from pregnant women at term than during the first trimester or from women who were not pregnant. This could not be accounted for by differences in differential blood counts. Significantly higher levels (P = < 0.05) of MCP-1 were released from PBMC preparations from pregnant compared with non-pregnant women. No 'rebound' increase in MCP-1 was observed on withdrawing progesterone support to the PBMC preparations. MCP-1 was secreted predominately from CD14+ cells with those from pregnant women producing more than those from non-pregnant women. There was no statistical difference in release of IL-8 or RANTES from either peripheral blood or PBMC preparations from pregnant or non-pregnant women. IL-8 and RANTES were secreted from CD14+ and CD14- cells, respectively. The hypothesis proposed is that the monocytes are fundamentally different in pregnancy and that measurement of MCP-1 has the potential to act as a marker of pregnancy status.
Authors:
F C Denison; R W Kelly; A A Calder
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  34     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-06     Completed Date:  1998-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  225-40     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD14 / blood
Cell Separation
Cells, Cultured
Chemokine CCL2 / blood,  secretion
Chemokine CCL5 / blood,  secretion
Chemokines / blood,  secretion*
Female
Humans
Interleukin-8 / blood,  secretion
Leukocytes, Mononuclear / immunology,  secretion
Middle Aged
Pregnancy / blood,  immunology*
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/Chemokines; 0/Interleukin-8

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