| Differential secretion of chemokines from peripheral blood in pregnant compared with non-pregnant women. | |
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MedLine Citation:
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PMID: 9350639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The maintenance of a normal pregnancy is dependent on the delicate interaction between the endocrine and the immune systems. Cytokines are thought to play a key role in pregnancy by way of local modulation of the immune system at the level of peripheral leukocytes. This study examined the potential of peripheral venous blood cultures from pregnant women throughout gestation and from non-pregnant women to produce the chemokines monocyte chemotactic protein-1 (MCP-1), interleukin-8 (IL-8) and RANTES. Significantly (P = < 0.001), higher levels of MCP-1 were released from peripheral blood cultures from pregnant women at term than during the first trimester or from women who were not pregnant. This could not be accounted for by differences in differential blood counts. Significantly higher levels (P = < 0.05) of MCP-1 were released from PBMC preparations from pregnant compared with non-pregnant women. No 'rebound' increase in MCP-1 was observed on withdrawing progesterone support to the PBMC preparations. MCP-1 was secreted predominately from CD14+ cells with those from pregnant women producing more than those from non-pregnant women. There was no statistical difference in release of IL-8 or RANTES from either peripheral blood or PBMC preparations from pregnant or non-pregnant women. IL-8 and RANTES were secreted from CD14+ and CD14- cells, respectively. The hypothesis proposed is that the monocytes are fundamentally different in pregnancy and that measurement of MCP-1 has the potential to act as a marker of pregnancy status. |
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Authors:
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F C Denison; R W Kelly; A A Calder |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 34 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1998-01-06 Completed Date: 1998-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 225-40 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, Edinburgh, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD14 / blood Cell Separation Cells, Cultured Chemokine CCL2 / blood, secretion Chemokine CCL5 / blood, secretion Chemokines / blood, secretion* Female Humans Interleukin-8 / blood, secretion Leukocytes, Mononuclear / immunology, secretion Middle Aged Pregnancy / blood, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/Chemokines; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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