Document Detail


Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy.
MedLine Citation:
PMID:  15695374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously identified a transgenic mouse model that developed pregnancy-associated hypertension (PAH) and intrauterine growth restriction (IUGR) by mating females expressing human angiotensinogen (hANG) with males expressing human renin (hRN). These phenotypic defects were not observed in the opposite type of mating combination, despite the feto-placental overexpression of hRN and hANG detected in both types of crossbreeding. Detailed analysis of transgene localization in the labyrinth and its permeability to the maternal circulation revealed that hRN produced in trophoblast giant cells was secreted into the maternal circulation, whereas hANG, produced in chorionic trophoblasts and trophoblastic epithelium, was undetectable in the maternal plasma, probably due to their distinct spatial and temporal expression in labyrinth. These results demonstrated that PAH and IUGR could be mediated by feto-placental hRN through its permeability to the maternal circulation, not by feto-placental hANG production. Furthermore, overexpression of maternally derived hANG in decidua and spiral arteries of pregnant females with PAH and IUGR raises the possibility of local activation of the renin-angiotensin system and its pathophysiological effects on placental hypoperfusion in complications of pregnancy. This study provides in vivo evidence that the cell-specific expression of RN and ANG in the feto-maternal interface impacts their differential roles in pregnancy.
Authors:
Eriko Takimoto-Ohnishi; Tomoko Saito; Junji Ishida; Junji Ohnishi; Fumihiro Sugiyama; Ken-Ichi Yagami; Akiyoshi Fukamizu
Related Documents :
18364614 - Pregnancy loss after first trimester viability in women with sickle cell trait: a preli...
14579154 - Developmental changes at the materno-embryonic interface in early pregnancy of the alpa...
15649334 - Expression of bcl-2 and p53 at the fetal-maternal interface of rhesus monkey.
25448734 - Post-hoc comparison of vitamin d status at three timepoints during pregnancy demonstrat...
20066674 - First trimester aneuploidy screening in the presence of a vanishing twin: implications ...
8623854 - The current status of multifetal pregnancy reduction.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-02-03
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  19     ISSN:  0888-8809     ISO Abbreviation:  Mol. Endocrinol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1361-72     Citation Subset:  IM    
Affiliation:
Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensinogen / genetics,  metabolism*
Animals
Female
Gene Expression / physiology
Mice
Mice, Transgenic
Placenta / metabolism*
Pregnancy / metabolism*
RNA, Messenger / metabolism
Renin / genetics,  metabolism*
Renin-Angiotensin System / physiology
Chemical
Reg. No./Substance:
0/RNA, Messenger; 11002-13-4/Angiotensinogen; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1a...
Next Document:  Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due ...