Document Detail


Differential roles of leptin in regulating cell migration in thyroid cancer cells.
MedLine Citation:
PMID:  20428831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excess body weight is associated with a moderately increased risk of thyroid cancer. Adipocyte-derived hormone, leptin, has been shown to enhance cell growth and migration in many cancer types. Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells. We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines. Expression of long-form leptin receptors was observed in all thyroid cancer cell lines. Leptin stimulation did not alter the expression levels of leptin, leptin receptor and sodium-iodide symporter. Cell growth and cell cycle were not changed after leptin treatment. However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells. In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.
Authors:
Shih-Ping Cheng; Pen-Hui Yin; Yuan-Ching Chang; Chen-Hsen Lee; Shih-Yuan Huang; Chin-Wen Chi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  23     ISSN:  1791-2431     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1721-7     Citation Subset:  IM    
Affiliation:
Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Follicular / metabolism*,  pathology
Apoptosis
Blotting, Western
Carcinoma / metabolism*,  pathology
Carcinoma, Papillary / metabolism*,  pathology
Cell Cycle
Cell Movement*
Cell Proliferation
Humans
Leptin / metabolism*
RNA, Messenger / genetics
Receptors, Leptin / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Thyroid Neoplasms / metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Leptin; 0/RNA, Messenger; 0/Receptors, Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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