| Differential roles of NADPH oxidases in vascular physiology and pathophysiology. | |
| | |
MedLine Citation:
|
PMID: 22202108 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Reactive oxygen species (ROS) are produced by all vascular cells and regulate the major physiological functions of the vasculature. Production and removal of ROS are tightly controlled and occur in discrete subcellular locations, allowing for specific, compartmentalized signaling. Among the many sources of ROS in the vessel wall, NADPH oxidases are implicated in physiological functions such as control of vasomotor tone, regulation of extracellular matrix and phenotypic modulation of vascular smooth muscle cells. They are involved in the response to injury, whether as an oxygen sensor during hypoxia, as a regulator of protein processing, as an angiogenic stimulus, or as a mechanism of wound healing. These enzymes have also been linked to processes leading to disease development, including migration, proliferation, hypertrophy, apoptosis and autophagy. As a result, NADPH oxidases participate in atherogenesis, systemic and pulmonary hypertension and diabetic vascular disease. The role of ROS in each of these processes and diseases is complex, and a more full understanding of the sources, targets, cell-specific responses and counterbalancing mechanisms is critical for the rational development of future therapeutics. |
| | |
Authors:
|
Angelica M Amanso; Kathy K Griendling |
Related Documents
:
|
17364218 - Prostaglandin e(2) production by high and low virulent strains of paracoccidioides bras... 7806348 - Immunomodulatory spectrum of lipids associated with mycobacterium avium serovar 8. 10402218 - Key enzymes of prostaglandin biosynthesis and metabolism. coordinate regulation of expr... 18842178 - Regulation of functional and regressing stages of corpus luteum development in mice. ro... 18848698 - The role of interferon gamma in regulation of cd4+ t-cells and its clinical implications. 9608318 - Biologic agents in the treatment of inflammatory rheumatic diseases. |
Publication Detail:
|
Type: Journal Article Date: 2012-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience (Scholar edition) Volume: 4 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
|
Languages: eng Pagination: 1044-64 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Division of Cardiology, Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Dr, Atlanta, GA 30322. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Role for TLRs in Moraxella-superantigen induced polyclonal B cell activation.
Next Document: Antiviral escape strategies developed by bunyaviruses pathogenic for humans.