Document Detail

Differential responses to distinct psychotropic agents of selectively bred dominant and submissive animals.
MedLine Citation:
PMID:  22982068     Owner:  NLM     Status:  Publisher    
Dominance and submissiveness are two opposite poles of behavior representing important functional elements in the development of social interactions. We previously demonstrated the inheritability of these traits by selective breeding based upon the dominant-submissive relationships (DSR) food competition paradigm. Continued multigenerational behavioral selection of Sabra mice yielded animal populations with strong and stable features of dominance and submissiveness. We found that these animals react differentially to stressogenic triggers, antidepressants and mood stabilizing agents. The anxiolytic compound diazepam (1.5mg/kg, i.p.) reduced anxiety-like behavior of submissive animals, but showed anxiogenic effects among dominant animals. In the Forced Swim test, the antidepressant paroxetine (1, 3 and 10mg/kg, i.p.) markedly reduced immobility of submissive animals, demonstrating antidepressant-like effect. In contrast, when administered to dominant animals, paroxetine caused extreme (frenetic) activity. The mood stabilizer lithium (0.4%, p.o.) selectively influenced dominant mice, without affecting the behavior of submissive animals. In summary, we describe here two distinct animal populations possessing strong dominant and submissive phenotypes. We suggest that these populations hold potential as tools for studying the molecular basis and pharmacogenetics of dominant and submissive behavior.
Elimelech Nesher; Moshe Gross; Serah Lisson; Tatiana Tikhonov; Gal Yadid; Albert Pinhasov
Related Documents :
22814898 - Effect of laser and led phototherapies on the healing of cutaneous wound on healthy and...
8701968 - Temporal alterations in basement membrane components in the pulmonary vasculature of th...
19343168 - The effect of hypoxic myocardial preconditioning is highly dependent on the light-dark ...
23626528 - Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anx...
7452498 - Decreased cerebral catabolism of [3h]histamine in vivo after s-adenosylmethionine admin...
11053298 - Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Molecular Biology, Ariel University Center, Ariel, Israel; Department of Life Science, Bar Ilan University, Ramat Gan, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of...
Next Document:  Event-related potential correlates of emergent inference in human arbitrary relational learning.