| Differential responses of tissue viscance and collateral resistance to histamine and leukotriene C4. | |
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MedLine Citation:
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PMID: 3182509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alterations in tissue viscance (Vti) and collateral resistance (Rcoll) are both used as indexes of peripheral lung responses. However, it is not known whether the two responses reflect the effects of activation of the same contractile elements. We measured differential responses in Vti and Rcoll to histamine and leukotriene (LT) C4 to determine whether each evoked a similar pattern of response. Using the wedged bronchoscope constant-flow technique, we measured Rcoll in lobar segments of anesthetized, paralyzed, open-chest, mechanically ventilated mongrel dogs. In addition, we measured (with an alveolar capsule) alveolar pressure (PA) within the segment under study. This allowed us to calculate Vti, the component of the PA change in phase with segment flow. Rcoll and Vti measurements were obtained under base-line conditions and after local delivery of aerosols generated from histamine and LTC4. In five out of five lobes studied with both histamine and LTC4, the fractional Rcoll response to histamine was greater than the fractional Rcoll response to LTC4. In contrast, in four out of five lobes examined, the fractional increase in Vti accompanying the histamine response was less than the fractional increase in Vti accompanying LTC4 administration. These data suggest that anatomically distinct contractile elements influence Vti and Rcoll insofar as LTC4 and histamine evoke quantitatively different changes in these two indexes of peripheral lung responses. |
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Authors:
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M S Ludwig; S A Shore; J J Fredberg; J M Drazen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 65 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-12-07 Completed Date: 1988-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1424-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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drug effects* Animals Dogs Female Histamine / pharmacology* Lung Compliance / drug effects Male Pulmonary Alveoli / drug effects, physiology SRS-A / pharmacology* Viscosity |
| Grant Support | |
ID/Acronym/Agency:
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HL-33099/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/SRS-A; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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