Document Detail


Differential responses of serum and salivary interleukin-6 to acute strenuous exercise.
MedLine Citation:
PMID:  15778897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical exercise is associated with elevation of serum levels of interleukin-6 (IL-6) because of its production in the muscles. The use of IL-6 measurements in saliva has been proposed in the field of immunopathology, mainly involving salivary gland disease. We evaluated the responses of serum and salivary IL-6 in two different groups of athletes submitted to different types of controlled strenuous exercise (spinning activity and maximal isokinetic test). Serum and salivary samples for IL-6 measurements, and serum samples for lactate and myoglobin determination before and after exercise, were obtained. Salivary IL-6 was measured by ELISA after dilution experiments and compared with results obtained by immunoradiometric assay. Spinning activity elicited significant increases in all the variables, and no correlation was found among the respective variations. A significant response to the isokinetic exercise was observed for serum IL-6, lactate and myoglobin only; no correlation was found between serum and salivary IL-6. Our study demonstrated that serum and salivary IL-6 responses to exercise are dissociated, possibly in relation to the lack of relationships between the systemic/muscular and the salivary routes of IL-6 production. Analytical issues that concern IL-6 measurement in saliva deserve attention, notably regarding the collection method used to absorb saliva. Concomitant monitoring of serum markers of inflammation, muscle metabolism and damage can provide information about muscle function properties and adaptations to physical effort in different types of athletes.
Authors:
M Minetto; A Rainoldi; M Gazzoni; M Terzolo; P Borrione; A Termine; L Saba; A Dovio; A Angeli; P Paccotti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-20
Journal Detail:
Title:  European journal of applied physiology     Volume:  93     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-21     Completed Date:  2005-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  679-86     Citation Subset:  IM    
Affiliation:
Clinica Medica Generale, Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, A.S.O. San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Enzyme-Linked Immunosorbent Assay
Exercise / physiology*
Female
Humans
Interleukin-6 / analysis*,  blood*
Male
Muscle, Skeletal / physiology
Saliva / immunology
Chemical
Reg. No./Substance:
0/Interleukin-6

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