Document Detail


Differential responses of immune cells to type I interferon contribute to host resistance to viral infection.
MedLine Citation:
PMID:  23084923     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Type I interferons (IFNs) are central to antiviral defense, but how they orchestrate immune cell function is incompletely understood. We determined that IFNs produced during murine cytomegalovirus (MCMV) infection differentially affect dendritic cells (DCs) and natural killer (NK) cells. IFNs induce cell-intrinsic responses in DCs, activating antiproliferative, antiviral, and lymphocyte-activating gene networks, consistent with high activity of the transcription factor STAT1 in these cells. By comparison, NK cells exhibit lower STAT1 expression and reduced IFN responsiveness. Rather, IFNs indirectly affect NK cells by inducing IL-15, which activates the transcription factor E2F and stimulates genes promoting cell expansion. IFN cell-intrinsic responses are necessary in DCs, but not NK cells, for MCMV resistance. Thus, sensitivity to IFN-induced cytokines and differences in IFN receptor signaling program immune cells to mount distinct responses that promote viral control.
Authors:
Thomas Baranek; Thien-Phong Vu Manh; Yannick Alexandre; Muhammad Ahmad Maqbool; Joaquin Zacarias Cabeza; Elena Tomasello; Karine Crozat; Gilles Bessou; Nicolas Zucchini; Scott H Robbins; Eric Vivier; Ulrich Kalinke; Pierre Ferrier; Marc Dalod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell host & microbe     Volume:  12     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc scientifique et technologique de Luminy, 13288 Marseille, France; Institut National de la Santé et de la Recherche Medicale (Inserm), UMR1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France.
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