Document Detail


Differential responses between CA1 pyramidal cells and granule cells to ischemic insult in rat hippocampal slices.
MedLine Citation:
PMID:  8742026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differential responses between CA1 pyramidal cells (PCs) and granule cells (GCs) to transient ischemic insults (oxygen and glucose deprivation, Hypo center dot G(-)) were studied in rat hippocampal slices using simultaneous recordings of membrane potentials and intracellular Ca2+ concentrations ([Ca2+]i). The average resting membrane potentials before Hypo center dot G(-) were significantly different between PCs (-66.5 +/- 1.5 mV) and GCs (-78.5 +/- 2.0 mV). In PCs, Hypo center dot G(-) produced an initial hyperpolarization and a subsequent rapid and large depolarization. In contrast, in GCs, Hypo center dot G(-) produced a gradual depolarization with an initial slight hyperpolarization. [Ca2+]i increased corresponding to the depolarization. The [Ca2+]i levels during Hypo center dot G(-) and after reoxygenation were significantly higher in the CA1 than in the dentate gyrus. These results suggest that PCs are more susceptible to Hypo center dot G(-) than GCs, as judged by the speed of depolarization and the elevation in [Ca2+]i.
Authors:
H Shimizu; A Mizuguchi; M Aoki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  203     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, Sapporo Medical University of School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / physiopathology*
Female
Glucose / pharmacology
Hippocampus / physiology*
Male
Membrane Potentials / physiology
Oxygen / pharmacology
Pyramidal Cells / physiology
Rats
Rats, Wistar
Time Factors
Chemical
Reg. No./Substance:
50-99-7/Glucose; 7782-44-7/Oxygen

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