Document Detail


Differential response of three cell types to dual stress of nitric oxide and radiation.
MedLine Citation:
PMID:  22453795     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The perception of toxicity to nitric oxide (NO) and irradiation (IR) by three different cell types has been studied. The three cell types are the macrophage like RAW264.7 cells, EL4 lymphoma cells, and splenocytes, which represent the different components of a tumor. These three cell types respond differently to NO donors (SNP and SNAP) and radiation treatment. The macrophages were found to be most radio-resistant and insensitive to NO donors. The innate resistance of the macrophages was not due to its antioxidant defense system since there was no significant activation of the enzymes (superoxide dismutases, catalase, and glutathione peroxidase) in RAW264.7 cells after NO donor and irradiation. But the cell cycle arrest of the three cell types was different from each other. The EL4 cells were found to arrest in the G2/M phase while the macrophages were found arrested in the G1 phase of the cell cycle. Such specific killing of the tumor cell in response to NO donor while sparing the macrophages can be of immense importance to radiotherapy.
Authors:
Fatema A Dhariwala; Himanshi Narang; Malini Krishna
Related Documents :
15662725 - The motility of glioblastoma tumour cells is modulated by intracellular cofilin express...
6617765 - Analysis of proportion regulation in slugs of dictyostelium discoideum using a monoclon...
21423715 - To lyse or not to lyse: transient-mediated stochastic fate determination in cells infec...
7890615 - Heparan sulfate-mediated cell aggregation. syndecans-1 and -4 mediate intercellular adh...
22899545 - Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy.
8512895 - Secretions of the biliary mucosa in experimental clonorchiasis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-28
Journal Detail:
Title:  Cell biology and toxicology     Volume:  -     ISSN:  1573-6822     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506639     Medline TA:  Cell Biol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunonutrition before and during radiochemotherapy: improvement of inflammatory parameters in head ...
Next Document:  Histological examination of vascular lesions caused by stent implantation in humans and in comparati...