| Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson's disease. | |
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MedLine Citation:
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PMID: 21953789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although movement impairment in Parkinson's disease includes slowness (bradykinesia), decreased amplitude (hypokinesia), and dysrhythmia, clinicians are instructed to rate them in a combined 0-4 severity scale using the Unified Parkinson's Disease Rating Scale motor subscale. The objective was to evaluate whether bradykinesia, hypokinesia, and dysrhythmia are associated with differential motor impairment and response to dopaminergic medications in patients with Parkinson's disease. Eighty five Parkinson's disease patients performed finger-tapping (item 23), hand-grasping (item 24), and pronation-supination (item 25) tasks OFF and ON medication while wearing motion sensors on the most affected hand. Speed, amplitude, and rhythm were rated using the Modified Bradykinesia Rating Scale. Quantitative variables representing speed (root mean square angular velocity), amplitude (excursion angle), and rhythm (coefficient of variation) were extracted from kinematic data. Fatigue was measured as decrements in speed and amplitude during the last 5 seconds compared with the first 5 seconds of movement. Amplitude impairments were worse and more prevalent than speed or rhythm impairments across all tasks (P < .001); however, in the ON state, speed scores improved exclusively by clinical (P < 10(-6) ) and predominantly by quantitative (P < .05) measures. Motor scores from OFF to ON improved in subjects who were strictly bradykinetic (P < .01) and both bradykinetic and hypokinetic (P < 10(-6) ), but not in those strictly hypokinetic. Fatigue in speed and amplitude was not improved by medication. Hypokinesia is more prevalent than bradykinesia, but dopaminergic medications predominantly improve the latter. Parkinson's disease patients may show different degrees of impairment in these movement components, which deserve separate measurement in research studies. © 2011 Movement Disorder Society. |
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Authors:
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Alberto J Espay; Joe P Giuffrida; Robert Chen; Megan Payne; Filomena Mazzella; Emily Dunn; Jennifer E Vaughan; Andrew P Duker; Alok Sahay; Sang Jin Kim; Fredy J Revilla; Dustin A Heldman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-09-23 |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 26 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: 2012-02-28 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 2504-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Movement Disorder Society. |
Affiliation:
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UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson's disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio 45267-0525, USA. alberto.espay@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Dopamine Agents / administration & dosage* Drug Monitoring / statistics & numerical data Humans Hypokinesia / drug therapy, physiopathology Levodopa / administration & dosage* Middle Aged Movement / drug effects* Neurologic Examination / statistics & numerical data* Neurology / statistics & numerical data Observer Variation Parkinson Disease / drug therapy*, physiopathology Videotape Recording |
| Grant Support | |
ID/Acronym/Agency:
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7R43NS065554-03/NS/NINDS NIH HHS; K23 MH092735-01A1/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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