| Differential response of enterocytes to vitamin D during embryonic development: induction of intestinal inorganic phosphate, D-glucose and calcium uptake. | |
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MedLine Citation:
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PMID: 7152480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chick intestine maintained in organ culture at day 20 of embryonic life responds to appropriate dose levels of 1,25-dihydroxyvitamin D3 or vitamin D3 in the culture medium by stimulation of Na+-dependent uptake of inorganic phosphate (Pj) and D-glucose as well as by increased calcium absorption. The intensity of each single response to vitamin D varies along the small intestine: Only the jejunum shows high vitamin D increments of all three transport systems under investigation. Inhibition of vitamin D responses by actinomycin D suggests the involvement of gene activation in the sterol's action of raising intestinal transport activities. Determination of the developmental pattern of each vitamin D-dependent transport system showed that only calcium absorption could be induced in undifferentiated cells on day 15, while complete expression of vitamin D action, including elevation of Na+-dependent uptake of D-glucose and Pj, required a fairly advanced state of epithelial maturation and was thus not observed before the final day 20 of embryonic development. This indicates a progressive change of hormone sensitivity of absorptive cells during differentiation. |
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Authors:
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H S Cross; M Peterlik |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 14 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 649-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism* Chick Embryo Glucose / metabolism* Intestinal Absorption / drug effects Intestines / drug effects*, embryology, metabolism Organ Culture Techniques Phosphates / metabolism* Sodium / pharmacology Vitamin D / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 1406-16-2/Vitamin D; 50-99-7/Glucose; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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