Document Detail


Differential rescue of light- and food-entrainable circadian rhythms.
MedLine Citation:
PMID:  18497298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When food is plentiful, circadian rhythms of animals are powerfully entrained by the light-dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift most of their circadian rhythms to match the food availability. We studied the basis for entrainment of circadian rhythms by food and light in mice with targeted disruption of the clock gene Bmal1, which lack circadian rhythmicity. Injection of a viral vector containing the Bmal1 gene into the suprachiasmatic nuclei of the hypothalamus restored light-entrainable, but not food-entrainable, circadian rhythms. In contrast, restoration of the Bmal1 gene only in the dorsomedial hypothalamic nucleus restored the ability of animals to entrain to food but not to light. These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms.
Authors:
Patrick M Fuller; Jun Lu; Clifford B Saper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  320     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-06-02     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1074-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Descriptor/Qualifier:
ARNTL Transcription Factors
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics,  physiology*
Biological Clocks / physiology*
Body Temperature
Cell Cycle Proteins / genetics
Circadian Rhythm / physiology*
Dorsomedial Hypothalamic Nucleus / metabolism*
Food*
Gene Expression
Gene Transfer Techniques
Light*
Mice
Motor Activity
Nuclear Proteins / genetics
Period Circadian Proteins
Starvation
Suprachiasmatic Nucleus / metabolism
Transcription Factors / genetics
Grant Support
ID/Acronym/Agency:
HL07901-08/HL/NHLBI NIH HHS; HL60292/HL/NHLBI NIH HHS; NS051609/NS/NINDS NIH HHS; NS057119/NS/NINDS NIH HHS; NS33987/NS/NINDS NIH HHS; P50 HL060292-08/HL/NHLBI NIH HHS; R01 NS033987-11/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/ARNTL Transcription Factors; 0/Arntl protein, mouse; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Cell Cycle Proteins; 0/Nuclear Proteins; 0/Per1 protein, mouse; 0/Per2 protein, mouse; 0/Period Circadian Proteins; 0/Transcription Factors
Comments/Corrections
Comment In:
Science. 2008 Oct 31;322(5902):675; author reply 675   [PMID:  18974333 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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