| Differential regulation of thyrotropin releasing hormone receptors in neoplastic rodent mammotropic, adrenocorticotropic and thyrotropic pituitary cells in culture. | |
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MedLine Citation:
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PMID: 6246145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modulation of the concentration of receptors for thyrotropin releasing hormone (TRH) is different in neoplastic mammotropic, adrenocorticotropic, and thyrotropic pituitary cells in culture. Hydrocortisone increases the TRH receptor concentration in mammotropic and adrenocorticotropic cells but has no effect in thyrotropic cells. B-estradiol increases the TRH receptor number in mammotropic cells but has no effect in adrenocorticotropic and thyrotropic cells. Both TRH and T3 decrease the receptor concentration in all three cell types. |
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Authors:
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V Peck; M C Gershengorn |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 50 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-07-26 Completed Date: 1980-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1144-6 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Estradiol / pharmacology Hydrocortisone / pharmacology Mice Pituitary Neoplasms / metabolism* Receptors, Cell Surface / drug effects, metabolism* Thyrotropin-Releasing Hormone / metabolism*, pharmacology Triiodothyronine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 24305-27-9/Thyrotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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