Document Detail

Differential regulation of sympathetic burst frequency and amplitude following acute hypoxia in humans.
MedLine Citation:
PMID:  22814671     Owner:  NLM     Status:  Publisher    
Current evidence suggests that the persistent sympathetic nerve activity (SNA), commonly observed following exposure to hypoxia (HX), is mediated by chemoreceptor sensitization and or baroreflex resetting. Evidence in humans and animals suggests that these reflexes may independently regulate the frequency (gating) and amplitude (neuronal recruitment) of SNA bursts. In humans (n=7), we examined the regulation of SNA following acute isocapnic HX (5 min; end-tidal PO(2) = 45 Torr) and euoxic hypercapnia (HC; 5 min; end-tidal PCO(2) = +10 from baseline). HX increased SNA burst frequency (21±7 to 28±8 Burst/min, P<0.05) and amplitude (99±10 to 125±19 au, P<0.05) as did HC (14±6 to 22±10 bursts/min, P<0.05 and 100±12 to 133±29 au, P<0.05 respectively). Burst frequency (26±7 bursts/min, P<0.05), but not amplitude (97±12 au), remained elevated 10 min post HX. The change in burst amplitude (but not frequency) was significantly related to the measured change in ventilation (r(2)=0.527, p<0.001). Both frequency and amplitude decreased during recovery following HC. These data indicate the differential regulation of pattern and magnitude of sympathetic outflow in humans with sympathetic persistence following HX being specific to burst frequency and not amplitude.
Craig Douglas Steinback; J Kevin Shoemaker
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-18
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1The University of Calgary.
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