| Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. | |
| | |
MedLine Citation:
|
PMID: 12566369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Twenty-hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that produces vasoconstriction and inhibition of renal tubular sodium transport. In Dahl rats, a 20-HETE deficiency plays a role in salt-sensitive (SS) hypertension. In humans, there are no data on regulation of 20-HETE by salt intake or on a role for this compound in SS hypertension. METHODS AND RESULTS: Thirteen salt-resistant (SR) and 13 SS hypertensive subjects had urine 20-HETE excretion measured during salt-loading and depletion. In all patients, 20-HETE was 66.6% higher in the salt-replete (1.75+/-0.25 micro g/h) than in the salt-depleted state (1.05+/-0.16, P<0.003). There was no difference in 20-HETE excretion between SR and SS patients in either state of salt balance. In SR patients, sodium excretion during salt-loading correlated with 20-HETE (r=0.61, P<0.03) but not with blood pressure. In contrast, in SS patients, sodium excretion did not correlate with 20-HETE but did correlate with blood pressure (r=0.66, P<0.02). Finally, in the SS group only, there was a negative correlation between body mass index and 20-HETE excretion (r=-0.79, P<0.002) that was present during both salt-loading and depletion. CONCLUSIONS: We demonstrate for the first time that 20-HETE excretion is regulated by salt intake in hypertension. We find a disrupted relationship between sodium excretion and 20-HETE in SS patients, which results in dependence of their salt excretion on blood pressure and may be related to the magnitude of their obesity. We conclude that salt-sensitivity of blood pressure in essential hypertension may result from impairment of a natriuretic mechanism dependent on 20-HETE. |
| | |
Authors:
|
Cheryl L Laffer; Michal Laniado-Schwartzman; Mong-Heng Wang; Alberto Nasjletti; Fernando Elijovich |
Related Documents
:
|
19262499 - Effects of salt substitute on pulse wave analysis among individuals at high cardiovascu... 7548049 - Alternate view on thermal stability of the dna duplex. 11230319 - Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive dahl salt-se... 19669669 - Pro-inflammatory cytokines of rat vasculature in doca-salt treatment. 11566959 - Omapatrilat in subtotal nephrectomy-salt hypertension: role of calcitonin gene-related ... 17142679 - Mechanics of nectar feeding in the orchid bee euglossa imperialis: pressure, viscosity ... 3179339 - The effects of thermal biofeedback and autogenic training of cardiovascular reactivity:... 1328979 - A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intr... 11430549 - Effects of tidal volume reduction in acute respiratory distress syndrome on gastric muc... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 107 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-02-04 Completed Date: 2003-02-13 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 574-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Lenox Hill Hospital, New York University School of Medicine, New York, USA. claffer@lenoxhill.net |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / drug effects Creatinine / urine Diet, Sodium-Restricted Female Furosemide / therapeutic use Humans Hydroxyeicosatetraenoic Acids / urine* Hypertension / diagnosis, etiology*, physiopathology, therapy Male Middle Aged Natriuresis / drug effects* Obesity / physiopathology Sodium / urine Sodium Chloride, Dietary* / adverse effects, diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
|
M01 RR00073/RR/NCRR NIH HHS; P01 34300//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxyeicosatetraenoic Acids; 0/Sodium Chloride, Dietary; 54-31-9/Furosemide; 60-27-5/Creatinine; 7440-23-5/Sodium; 79551-86-3/20-hydroxy-5,8,11,14-eicosatetraenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial production of C-type natriuretic peptide in chronic heart failure.
Next Document: Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator ...