Document Detail

Differential regulation of myometrial prostaglandin production by changes in length.
MedLine Citation:
PMID:  18226632     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine whether stretching and shortening of human myometrial strips alters prostaglandin production. STUDY DESIGN: We measured 6-keto prostaglandin F1alpha (PGF1alpha; a PGI2 metabolite) and PGF2alpha in the contraction baths of myometrial strips that were obtained at cesarean delivery from 5 term pregnant women. Fluid was collected after the stretching and after the strip lengths were decreased by 4%, 6%, or 8%. Prostaglandin concentrations were measured in triplicate by competitive enzyme immunoassay and compared by Kruskal-Wallis tests. RESULTS: Stretching myometrial strips increased the production of 6-keto PGF1alpha by 31%, but not PGF2alpha. Shortening strips had little effect on 6-keto PGF1alpha production, but increased PGF2alpha production by 158%. CONCLUSION: Stretching myometrial strips from pregnant women increases synthesis of PGI2; shortening strips increases synthesis of PGF2alpha. Differential prostaglandin synthesis that is related to myometrial stretching and shortening could play a role in uterine quiescence during gestation and increased contractility during parturition.
William W Hurd; Shawn G Gibbs; Kari A Rudinsky
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225.e1-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, University Hospitals/MacDonald Women's Hospital, Cleveland, OH, USA.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism*
Myometrium / metabolism*,  physiology*
Pregnancy Trimester, Third
Uterine Contraction / metabolism,  physiology
Reg. No./Substance:
58962-34-8/6-Ketoprostaglandin F1 alpha

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