Document Detail


Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake.
MedLine Citation:
PMID:  10234028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological consequences of activating corticotropin-releasing factor receptor type 2 (CRF2) are not fully understood. The neuroanatomic distribution of this CRF receptor family member is consistent with roles in mediating the actions of CRF and similar ligands on food intake control and integrative aspects of stress-related behaviors. However, CRF2 expression in the adult rat is not influenced by stress, corticosterone (CORT), or food intake. In immature rat we have demonstrated striking downregulation of CRF2mRNA in hypothalamic ventromedial nucleus (VMH) after 24 hr of maternal deprivation, a paradigm consisting of both physiological/psychological stress and food deprivation. The current study aimed to distinguish which element or elements of maternal deprivation govern CRF2mRNA expression by isolating the effects of food intake and discrete maternal sensory cues on CRF2mRNA levels in VMH and in reciprocally communicating amygdala nuclei. In maternally deprived pups, CRF2mRNA levels in VMH and basomedial (BMA) and medial (MEA) amygdala nuclei were 62, 72, and 102% of control levels, respectively. Sensory inputs of grooming and handling as well as of the pups' own suckling activity-but not food intake-fully restored CRF2mRNA expression in VMH. In contrast, all manipulations tended to increase CRF2mRNA levels in BMA of maternally deprived rats, and surrogate grooming increased CRF2mRNA expression significantly above that of nondeprived controls. CRF2mRNA expression was not influenced significantly by plasma adrenocorticotropic hormone (ACTH) and CORT levels. Thus, in the immature rat, (1) CRF2 expression is regulated differentially in hypothalamic and amygdala regions, and (2) CRF2mRNA levels in VMH are governed primarily by maternal or suckling-derived sensory input rather than food intake or peripheral stress hormones. These findings indicate a region-specific regulation of CRF2mRNA, supporting the participation of the receptor in neurochemically defined circuits integrating sensory cues to influence specific behavioral and visceral functions.
Authors:
M Eghbal-Ahmadi; S Avishai-Eliner; C G Hatalski; T Z Baram
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  19     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3982-91     Citation Subset:  IM    
Affiliation:
Departments of Anatomy and Neurobiology and Pediatrics, University of California at Irvine, Irvine, California 92697-4475, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Amygdala / metabolism*
Animals
Corticosterone / blood
Down-Regulation
Feeding Behavior / physiology*
Hypothalamus, Middle / metabolism*
Rats
Rats, Sprague-Dawley
Receptors, Corticotropin-Releasing Hormone / physiology*
Grant Support
ID/Acronym/Agency:
HD 34975/HD/NICHD NIH HHS; NS 28912/NS/NINDS NIH HHS; R01 NS028912-06/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Corticotropin-Releasing Hormone; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone
Comments/Corrections

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