Document Detail


Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.
MedLine Citation:
PMID:  15701643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
c-Jun is a transcription factor that plays an important role in regulating cell growth, apoptosis, differentiation, and transformation. The transcriptional activity of c-Jun can be regulated by both phosphorylation and sumoylation. It has also been shown that c-Jun transcription can be regulated by SuPr-1, an alternatively spliced form of SUMO-specific protease 2 (SENP2). However, the ability of SuPr-1 to enhance c-Jun transcription is dependent on promyelocytic leukemia but is independent of the desumoylation activity of SuPr-1. Here, we show that SUMO-specific protease 1 (SENP1) also markedly enhances the transcription activity of c-Jun. The action of SENP1 on c-Jun transcription is independent of the sumoylation and phosphorylation status of c-Jun but is critically dependent on the desumoylation activity of SENP1. We further show that p300 is essential for SENP1 to enhance c-Jun-dependent transcription because SENP1 can desumoylate the CRD1 domain of p300, thereby releasing the cis-repression of CRD1 on p300. Thus, two SUMO-specific proteases regulate c-Jun-dependent transcription through entirely different mechanisms.
Authors:
Jinke Cheng; Neil D Perkins; Edward T H Yeh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-02-08
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  280     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-06-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14492-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
COS Cells
Cell Line, Tumor
Cysteine Endopeptidases / metabolism
Endopeptidases / metabolism
Gene Expression Regulation*
Glutathione Transferase / metabolism
Histone Deacetylases / metabolism
Humans
Models, Biological
Models, Genetic
Nuclear Proteins / metabolism
Phosphorylation
Plasmids / metabolism
Protein Binding
Protein Structure, Tertiary
Proto-Oncogene Proteins c-jun / metabolism*
RNA Interference
Small Ubiquitin-Related Modifier Proteins / metabolism*
Trans-Activators / metabolism
Transcription, Genetic*
Transcriptional Activation
Transfection
Grant Support
ID/Acronym/Agency:
R01 CA80089/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Nuclear Proteins; 0/Proto-Oncogene Proteins c-jun; 0/Small Ubiquitin-Related Modifier Proteins; 0/Trans-Activators; EC 2.5.1.18/Glutathione Transferase; EC 3.4.-/Endopeptidases; EC 3.4.-/SENP1 protein, human; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.-/SENP2 protein, human; EC 3.4.22.-/SENP6 protein, human; EC 3.5.1.98/Histone Deacetylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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