Document Detail

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell.
MedLine Citation:
PMID:  18793169     Owner:  NLM     Status:  MEDLINE    
Recent evidence indicates that treatment of pancreatic beta-cells with long chain fatty acids can lead to the development of an ER (endoplasmic reticulum) stress response. This is manifest as the activation of some components of the PERK [RNA-dependent protein kinase-like ER eIF2alpha (eukaryotic initiation factor 2alpha) kinase]-dependent arm of ER stress and is seen most dramatically when cells are treated with long-chain saturated fatty acids (e.g. palmitate). By contrast, the equivalent mono-unsaturates (e.g. palmitoleate) are much less effective and they can even attenuate the ER stress response to palmitate. This may be due to the regulation of eIF2alpha phosphorylation in cells exposed to mono-unsaturates. The present review discusses the differential effects of saturated and mono-unsaturated fatty acids on ER stress in beta-cells and considers the extent to which regulation of this pathway may be involved in mediating their effects on viability.
Eleftheria Diakogiannaki; Noel G Morgan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  36     ISSN:  0300-5127     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  959-62     Citation Subset:  IM    
Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK.
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MeSH Terms
Cell Line
Cell Survival
Endoplasmic Reticulum / metabolism*
Fatty Acids* / chemistry,  metabolism
Insulin-Secreting Cells* / cytology,  metabolism
Oxidative Stress*
Reg. No./Substance:
0/Fatty Acids

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