| Differential regulation of EHD3 in human and mammalian heart failure. | |
| | |
MedLine Citation:
|
PMID: 22406195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electrical and structural remodeling during the progression of cardiovascular disease is associated with adverse outcomes subjecting affected patients to overt heart failure (HF) and/or sudden death. Dysfunction in integral membrane protein trafficking has long been linked with maladaptive electrical remodeling. However, little is known regarding the molecular identity or function of these intracellular targeting pathways in the heart. Eps15 homology domain-containing (EHD) gene products (EHD1-4) are polypeptides linked with endosomal trafficking, membrane protein recycling, and lipid homeostasis in a wide variety of cell types. EHD3 was recently established as a critical mediator of membrane protein trafficking in the heart. Here, we investigate the potential link between EHD3 function and heart disease. Using four different HF models including ischemic rat heart, pressure overloaded mouse heart, chronic pacing-induced canine heart, and non-ischemic failing human myocardium we provide the first evidence that EHD3 levels are consistently increased in HF. Notably, the expression of the Na/Ca exchanger (NCX1), targeted by EHD3 in heart is similarly elevated in HF. Finally, we identify a molecular pathway for EHD3 regulation in heart failure downstream of reactive oxygen species and angiotensin II signaling. Together, our new data identify EHD3 as a previously unrecognized component of the cardiac remodeling pathway. |
| | |
Authors:
|
Hjalti Gudmundsson; Jerry Curran; Farshid Kashef; Jedidiah S Snyder; Sakima A Smith; Pedro Vargas-Pinto; Ingrid M Bonilla; Robert M Weiss; Mark E Anderson; Philip Binkley; Robert B Felder; Cynthia A Carnes; Hamid Band; Thomas J Hund; Peter J Mohler |
Related Documents
:
|
17584685 - Heart rate variability as a predictor of sudden cardiac death. 2954935 - Cardiac involvement in a patient with limb-girdle muscular dystrophy. 17317365 - Usefulness of either or both left and right bundle branch block at baseline or during f... 11110045 - Sudden unexpected death as a consequence of indinavir-induced nephropathy. a case report. 16914105 - Management of acute pulmonary edema in the emergency department. 234665 - Arrhythmias following cardiac surgery: relation to serum digoxin levels. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-03 |
Journal Detail:
|
Title: Journal of molecular and cellular cardiology Volume: 52 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-16 Completed Date: 2012-08-07 Revised Date: 2013-05-03 |
Medline Journal Info:
|
Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
|
Languages: eng Pagination: 1183-90 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
metabolism Animals Carrier Proteins / genetics, metabolism* Case-Control Studies Cells, Cultured Dogs Gene Expression Regulation* Heart Failure / enzymology, metabolism*, pathology Heart Ventricles / enzymology, metabolism*, pathology Humans Male Mice Mice, Inbred C57BL Myocytes, Cardiac / enzymology, metabolism NADPH Oxidase / metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species / metabolism Sodium-Calcium Exchanger / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
CA105489/CA/NCI NIH HHS; CA116552/CA/NCI NIH HHS; CA87986/CA/NCI NIH HHS; CA99163/CA/NCI NIH HHS; F32 HL114252/HL/NHLBI NIH HHS; HL073986/HL/NHLBI NIH HHS; HL079031/HL/NHLBI NIH HHS; HL083422/HL/NHLBI NIH HHS; HL084583/HL/NHLBI NIH HHS; HL089836/HL/NHLBI NIH HHS; HL096805/HL/NHLBI NIH HHS; HL62494/HL/NHLBI NIH HHS; HL70250/HL/NHLBI NIH HHS; R01 HL073986/HL/NHLBI NIH HHS; R01 HL083422/HL/NHLBI NIH HHS; R01 HL083422-07/HL/NHLBI NIH HHS; R01 HL084583/HL/NHLBI NIH HHS; R01 HL084583-07/HL/NHLBI NIH HHS; R01 HL113001/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/EHD3 protein, human; 0/Reactive Oxygen Species; 0/Sodium-Calcium Exchanger; 0/sodium-calcium exchanger 1; 11128-99-7/Angiotensin II; EC 1.6.3.1/NADPH Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stochastic formulation of ecological models and their applications.
Next Document: Introducing GRADE across the NICE clinical guideline program.