Document Detail


Differential regulation of APP secretion by apolipoprotein E3 and E4.
MedLine Citation:
PMID:  8624107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The apolipoprotein E isozyme, apolipoprotein E4, has been implicated as a risk factor for Alzheimer's disease. One reason for the increased risk may be that apolipoprotein E binds to the A beta peptide, but there may be other factors as well. We show that apolipoprotein E is a potent regulator of the secretion of amyloid precursor protein. In cultures of PC12 cells, nanomolar levels of apolipoprotein E3 induce a rapid decrease in the secretion of APP, being observable in 30 min. and stable over 24 hours. Apolipoprotein E4, in contrast, increases secretion of APP over a similar time course. Reciprocal changes occur in cellular amyloid precursor protein. Differential characteristics are also seen in apo E binding to the cells, where apo E4 binds over a slower time course than apo E3. These results suggest a novel mechanism by which apolipoprotein E may be influencing the metabolism of amyloid precursor protein.
Authors:
B L Wolozin; J Basaric-Keys; R Canter; Y Li; D Vanderputten; T Sunderland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  777     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-06-14     Completed Date:  1996-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  IM    
Affiliation:
Section on Geriatric Psychiatry, NIMH, Bethesda, Maryland 20892, USA. ben@codon.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein Precursor / metabolism*
Animals
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E / physiology*
PC12 Cells / metabolism
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/Apolipoprotein E3; 0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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