Document Detail

Differential regulation of AP-1 DNA-binding activity by D1 and D2 dopamine receptor antagonists in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle.
MedLine Citation:
PMID:  10100204     Owner:  NLM     Status:  MEDLINE    
The effect of D1 and D2 dopamine receptor antagonists on the DNA-binding activity of the AP-1 transcription factor was studied in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle. In the caudate-putamen, vehicle-treated rats showed increased AP-1 DNA-binding activity, which appeared to be reversed completely by treatment with the D1 receptor antagonist SCH23390 (1 mg kg-1 i.p.) and partially by the D2 antagonist sulpiride (50 mg kg-1 i.p.). In the globus pallidus, vehicle and sulpiride did not induce AP-1, while SCH23390 increased it significantly. This induction was much more prominent in the 6-OHDA-lesioned hemisphere than in the intact hemisphere. The present study suggests that in the caudate-putamen, dopamine-depletion induces long-lasting enhancement of AP-1 DNA-binding activity via activation of D1 receptors and the simultaneous activation of D2 receptors facilitate it. However, in the globus pallidus of the 6-OHDA-lesioned hemisphere, D1 but not D2 antagonism induces AP-1 in certain cell populations which may be distinct from those expressing AP-1 upon stimulation of D2 receptors.
K Kashihara; K Akiyama; T Ishihara; Y Manabe; K Abe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  21     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Department of Neurology, Okayama University Medical School, Japan.
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MeSH Terms
Caudate Nucleus / drug effects,  metabolism
Corpus Striatum / drug effects*,  metabolism
DNA-Binding Proteins / metabolism*
Dopamine Antagonists / pharmacology*
Functional Laterality
Globus Pallidus / drug effects,  metabolism
Oxidopamine / toxicity
Prosencephalon / drug effects*,  metabolism
Putamen / drug effects,  metabolism
Rats, Sprague-Dawley
Receptors, Dopamine D1 / antagonists & inhibitors
Receptors, Dopamine D2 / antagonists & inhibitors
Transcription Factor AP-1 / metabolism*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Dopamine Antagonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Transcription Factor AP-1; 1199-18-4/Oxidopamine

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