Document Detail

Differential registration of two types of radionuclides on macroautoradiograms for studying coronary circulation: concise communication.
MedLine Citation:
PMID:  6308190     Owner:  NLM     Status:  MEDLINE    
Double-radionuclide autoradiography proved to be feasible using combinations of Tc-99m and I-125, or Tc-99m and C-14. Because of the short half-life of Tc-99m (6 hr), we first registered Tc-99m on x-ray film. Given an adequate Tc-99m:I-125 activity ratio of 20:1, the exposure duration for Tc-99m was still too short for I-125 to blacken the x-ray film. The pure emission from C-14 is completely absorbed by a thin aluminum sheet--hence no problem there. After the decay of Tc-99m, therefore, it was entirely feasible to continue autoradiography with I-125 (T1/2 = 60.2 days) or C-14 (T1/2 = 5730 yr). Based on these conditions, we applied (a) tracer microspheres labeled with I-125 and Tc-99m to define the respective perfusion areas of the left anterior descending, septal, and left circumflex coronary arteries of the beating heart, and (b) Tc-99m pyrophosphate and C-14 antipyrine to demarcate respectively the localization of the infarct-avid substance and the regional blood flow. We verified the first procedure with postmortem angiography and the second with histochemistry.
H Tomoike; I Ogata; Y Maruoka; K Sakai; T Kurozumi; M Nakamura
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  24     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  IM    
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MeSH Terms
Carbon Radioisotopes / diagnostic use*
Coronary Circulation*
Diphosphates / diagnostic use
Iodine Radioisotopes / diagnostic use*
Myocardial Infarction / physiopathology
Technetium / diagnostic use*
Technetium Tc 99m Pyrophosphate
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Diphosphates; 0/Iodine Radioisotopes; 0/Technetium Tc 99m Pyrophosphate; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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