| Differential registration of two types of radionuclides on macroautoradiograms for studying coronary circulation: concise communication. | |
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MedLine Citation:
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PMID: 6308190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Double-radionuclide autoradiography proved to be feasible using combinations of Tc-99m and I-125, or Tc-99m and C-14. Because of the short half-life of Tc-99m (6 hr), we first registered Tc-99m on x-ray film. Given an adequate Tc-99m:I-125 activity ratio of 20:1, the exposure duration for Tc-99m was still too short for I-125 to blacken the x-ray film. The pure emission from C-14 is completely absorbed by a thin aluminum sheet--hence no problem there. After the decay of Tc-99m, therefore, it was entirely feasible to continue autoradiography with I-125 (T1/2 = 60.2 days) or C-14 (T1/2 = 5730 yr). Based on these conditions, we applied (a) tracer microspheres labeled with I-125 and Tc-99m to define the respective perfusion areas of the left anterior descending, septal, and left circumflex coronary arteries of the beating heart, and (b) Tc-99m pyrophosphate and C-14 antipyrine to demarcate respectively the localization of the infarct-avid substance and the regional blood flow. We verified the first procedure with postmortem angiography and the second with histochemistry. |
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Authors:
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H Tomoike; I Ogata; Y Maruoka; K Sakai; T Kurozumi; M Nakamura |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 24 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-09-09 Completed Date: 1983-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 693-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Animals Autoradiography Carbon Radioisotopes / diagnostic use* Coronary Circulation* Diphosphates / diagnostic use Dogs Histocytochemistry Iodine Radioisotopes / diagnostic use* Myocardial Infarction / physiopathology Technetium / diagnostic use* Technetium Tc 99m Pyrophosphate |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Diphosphates; 0/Iodine Radioisotopes; 0/Technetium Tc 99m Pyrophosphate; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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