| Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas. | |
| | |
MedLine Citation:
|
PMID: 11740048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hürthle cell carcinomas behave as the most aggressive variant of differentiated thyroid carcinoma of follicular origin, with frequent recurrences and higher morbidity. Its differential diagnosis with Hürthle cell adenoma remains a problem for the clinician and for the pathologist. The vertebrate lectins, galectin-1 and galectin-3 have been implicated in the regulation of cellular growth, differentiation, and malignant transformation in thyroid neoplasms. Galectin-3, a beta-galactoside binding protein, has been recently found to be highly expressed in papillary and follicular carcinomas. The current study was undertaken to investigate immunohistochemical reactivity for galectin-3 of thyroid specimen tissues with Hürthle cell adenomas (n = 14) and carcinomas (n = 17), follicular (n = 14) and papillary (n = 11) carcinomas, colloid goiter (n = 30), Hashimoto's thyroiditis (n = 11), follicular adenoma (n = 9), and normal thyroid tissues (n = 18). Follicular (78.5%) and papillary (82.0%) carcinomas were frequently reactive for galectin-3, more often when some H rthle cells were present. There was no galectin-3 immunostaining in any of the specimens from Hashimoto's thyroiditis, colloid goiters or normal thyroid samples, whereas only one case of follicular adenoma was found positive (11.1%). By contrast, galectin-3 immunostaining in Hürthle cell carcinomas was significantly higher (59%) than in H rthle cell adenomas (7.1), p < 0.05). These results suggest that galectin-3 may potentially serve as a marker in difficult differential diagnosis cases involving Hürthle cell adenomas and Hürthle cell carcinomas. |
| | |
Authors:
|
M C Nascimento; H Bisi; V A Alves; A Longatto-Filho; C T Kanamura; G Medeiros-Neto |
Related Documents
:
|
12056638 - Effect of calcitriol on proliferation of tt cells and on expression of calcitonin gene. 6286688 - Guinea pig adrenocortical cells: in vitro characterization of separated zonal cell types. 6398218 - Tissue calmodulin levels in normal and graves' thyroids. 7538778 - Mammary and extramammary paget's disease: expression of ca 15-3, ka-93, ca 19-9 and cd4... 16659898 - Rapid isolation of mesophyll cells from leaves of soybean for photosynthetic studies. 9786358 - Follicular center cell lymphoma with an extremely high content of t cells: case report ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Endocrine pathology Volume: 12 ISSN: 1046-3976 ISO Abbreviation: Endocr. Pathol. Publication Date: 2001 |
Date Detail:
|
Created Date: 2001-12-12 Completed Date: 2002-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
|
Thyroid Unit (LIM-25), Univ Sao Paulo Med School, Sao Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma, Follicular
/
diagnosis* Adenoma, Oxyphilic / diagnosis* Antigens, Differentiation / diagnostic use* Cell Count Diagnosis, Differential Galectin 3 Goiter / metabolism, pathology Humans Immunohistochemistry Lectins / diagnostic use* Thyroid Gland / anatomy & histology, metabolism, pathology Thyroid Neoplasms / diagnosis* Thyroiditis, Autoimmune / metabolism, pathology Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Differentiation; 0/Galectin 3; 0/Lectins; 0/Tumor Markers, Biological |
| Comments/Corrections | |
Comment In:
|
Endocr Pathol. 2001 Fall;12(3):255-7
[PMID:
11740046
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The MEN1 gene and associated diseases: an update.
Next Document: Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more co...