Document Detail

Differential prostacyclin production by human umbilical vasculature.
MedLine Citation:
PMID:  3276285     Owner:  NLM     Status:  MEDLINE    
Using the avidin-biotin immunohistochemical technique with rabbit antihuman 6-keto-prostaglandin (PG)-F1 alpha (6KPGF), we studied the distribution of the stable prostacyclin metabolite, 6KPGF, in 14 formaldehyde-fixed human umbilical cords. All umbilical veins demonstrated intense endothelial cell staining. None of the arteries stained. To corroborate the immunohistochemical findings, three fresh umbilical cords were dissected to separate arteries from veins and then were incubated in oxygenated tissue baths containing Ringer's lactate (37 degrees C) for 30 minutes. Cumulative 6KPGF production as measured by radioimmunoassay of tissue effluents was markedly different between arteries and veins with the umbilical vein producing the largest quantity of 6KPGF. Thus, immunohistochemistry and ex vivo capacitance studies suggest that there is a differential distribution of 6KPGF in human umbilical arteries and veins.
J G Harold; R J Siegel; G A FitzGerald; P Satoh; M C Fishbein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  112     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-01-25     Completed Date:  1988-01-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  AIM; IM    
Division of Cardiology, Cedars-Sinai Medical Center, UCLA School of Medicine 90048.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism
Blood Vessels / metabolism
Epoprostenol / biosynthesis*
Infant, Newborn
Umbilical Cord / blood supply*
Grant Support
17413//PHS HHS; 17651//PHS HHS; F32 HL06986-01/HL/NHLBI NIH HHS
Reg. No./Substance:
35121-78-9/Epoprostenol; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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