| Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations. | |
| | |
MedLine Citation:
|
PMID: 19965847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). METHODS: The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean+/-SD=29.91+/-5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. RESULTS: At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. CONCLUSION: The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas. |
| | |
Authors:
|
Naroa Ibarretxe-Bilbao; Blanca Ramirez-Ruiz; Carme Junque; Maria Jose Marti; Francesc Valldeoriola; Nuria Bargallo; Silvia Juanes; Eduardo Tolosa |
Related Documents
:
|
21839587 - Anti-cardiolipin and anti-beta 2-glycoprotein i antibodies in celiac disease. 17078067 - Computerized posturography balance assessment of patients with bilateral ventralis inte... 15985587 - "applause sign" helps to discriminate psp from ftd and pd. 9918347 - Planning and executing an action in parkinson's disease. 10085447 - Tuberculosis in active dialysis patients in jeddah. 2916027 - Frequency and determinants of adverse reactions induced by high-osmolality contrast media. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-03 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 81 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-04 Completed Date: 2010-06-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 650-7 Citation Subset: IM |
Affiliation:
|
Centro de Investigaci?n en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Cl?nic de Barcelona, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Atrophy / epidemiology, pathology Brain / pathology* Cognition Disorders / diagnosis, epidemiology Diagnosis, Differential Disease Progression Female Follow-Up Studies Hallucinations / epidemiology* Humans Magnetic Resonance Imaging Male Neuropsychological Tests Parkinson Disease / epidemiology*, pathology* Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Safety of Performing CT-angiography in Stroke Patients Treated with Intravenous Thrombolysis.
Next Document: Aneurysm occlusion in elderly patients with aneurysmal subarachnoid haemorrhage: a cost-utility anal...