| Differential profile analysis of urinary cytokines in patients with overactive bladder. | |
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MedLine Citation:
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PMID: 21487829 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION AND HYPOTHESIS: We hypothesize that overactive bladder (OAB) can produce inflammatory cytokines due to afferent neural plasticity or urothelial dysfunction. This study aimed to detect abnormal cytokine levels in urine of patients with OAB compared to urinary tract infections (UTI) and controls. METHODS: This was a prospective, single blind study including 20 premenopausal women (control), 20 with OAB and 16 with UTI. Urine samples were collected, centrifuged, and stored (-80°C). Urinary total proteins were quantified and detected by antibody-based array chip for release of 120 human cytokines in the two groups relative to the controls. RESULTS: Majority of cytokines showed the same expression in the OAB compared with the controls. Cytokines exclusively expressed in OAB were: monocyte chemoattractant protein (MCP) 1, TARC, PARC, and Fas/TNFRSF6. MCP-2, MCP-3, tumor necrosis factor-β, GCSF and eotaxin-3 showed a shared expression in UTI and OAB. Conversely, few of the cytokines were downregulated in OAB (IL-5, IL-6, IL-7, and GM-CSF). CONCLUSIONS: Taken together, the results suggest that a subset of inflammatory cytokines and chemokines provides a framework for development of highly optimized urinary biomarker assay for differential diagnosis and treatment of OAB. |
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Authors:
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Gamal Ghoniem; Nuzhat Faruqui; Mostafa Elmissiry; Ayman Mahdy; Hassan Abdelwahab; Mathew Oommen; Asim B Abdel-Mageed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-13 |
Journal Detail:
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Title: International urogynecology journal and pelvic floor dysfunction Volume: - ISSN: 1433-3023 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9514583 Medline TA: Int Urogynecol J Pelvic Floor Dysfunct Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section of Voiding Dysfunction and Female Urology, Cleveland Clinic Florida, Weston, FL, USA, ghonieg@ccf.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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