Document Detail

Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysis.
MedLine Citation:
PMID:  9298429     Owner:  NLM     Status:  MEDLINE    
Fava et al., Am. J. Psychiatry 150 (1993)1158-1163, have recently proposed the existence of a sub-type of depressed patients who experience anger attacks. These investigators hypothesized that patients who experience anger attacks will respond better to a specific selective serotonin reuptake inhibitor (SSRI) medication than will depressed patients who do not experience anger attacks. Using a non-randomized, archival treatment methodology, 158 patients were classified as either high angry hostile (n = 83) or low angry hostile (n = 75). These patients had been treated with either a primarily noradrenergic reuptake inhibitor (desipramine) a SSRI (sertraline or paroxetine), or the combined serotonin and norepinephrine reuptake inhibitor (SNRI), venlafaxine. A 2 (high angry hostile/low angry hostile) x 3 (medication type) analysis of variance (ANOVA) was non-significant, indicating no differential treatment effects.
R M Bagby; S H Kennedy; D R Schuller; S E Dickens; C E Minifie; A Levitt; R Joffe
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of affective disorders     Volume:  45     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
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MeSH Terms
1-Naphthylamine / analogs & derivatives,  therapeutic use
Ambulatory Care
Analysis of Variance
Cyclohexanols / therapeutic use
Depressive Disorder / drug therapy*,  psychology
Desipramine / therapeutic use
Paroxetine / therapeutic use
Retrospective Studies
Serotonin Uptake Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Cyclohexanols; 0/Serotonin Uptake Inhibitors; 134-32-7/1-Naphthylamine; 50-47-5/Desipramine; 61869-08-7/Paroxetine; 79617-96-2/Sertraline; 93413-69-5/venlafaxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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