Document Detail

Differential penetration of ototopicals and water through tympanostomy tubes.
MedLine Citation:
PMID:  16094106     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the penetration of ototopicals and water through tympanostomy tubes (TT) using a physical model. STUDY DESIGN: An in vitro model was created to measure the ability of various solutions to penetrate a variety of TT. METHODS: A TT was placed through a perforation (myringotomy) in a silastic sheet (tympanic membrane) fixed between the ends of two 1 mL syringes. Measurements were obtained of the maximum height various liquids (tap water, 2% soapy water, ocean water, ofloxacin otic, corticosporin otic, and ciprofloxacin/dexamethasone otic) achieved before penetrating different TTs (1.0 mm or 1.27 mm Paparella silicone, 1.14 mm or 1.27 mm Reuter Bobbin titanium, 1.27 mm Collar Button fluoroplastic or 1.14 mm T-type silicone). RESULTS: Two percent soapy water was significantly more permeable than water and ocean water in all tubes studied. Ciprofloxacin/dexamethasone otic was significantly more permeable than tap water, ocean water, and ofloxacin otic in only the Collar Button fluoroplastic TT. Our results suggest that titanium TTs are more permeable than other TT. Otherwise, ototopicals, tap water, and ocean water behaved similarly across all TT studied. CONCLUSIONS: Our results demonstrate that ototopicals, tap water, and ocean water behave similarly with regard to TT penetration. Ciprofloxacin/dexamethasone otic may have better penetration than other ototopicals. Titanium TT may be easier to penetrate than other TT.
Lee P Smith; Jennifer L Smullen; Ramzi T Younis
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  115     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1367-70     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, University of Miami School of Medicine, Miami, FL 33136, U.S.A.
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MeSH Terms
Administration, Topical
Anti-Bacterial Agents / administration & dosage,  pharmacokinetics*
Biological Availability
Equipment Design
Equipment Safety
Middle Ear Ventilation / instrumentation*
Models, Biological
Risk Factors
Sensitivity and Specificity
Water / administration & dosage*
Reg. No./Substance:
0/Anti-Bacterial Agents; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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