Document Detail


Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques.
MedLine Citation:
PMID:  19187427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases.
METHODS: We compared the in vivo infectivity and pathogenicity of a CCR5-tropic SHIV(SF162 P4) after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4(+) T cell counts and clinical signs were monitored.
RESULTS: Both rhesus and pig-tailed macaques are similarly susceptible to SHIV(SF162 P4) infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4(+) T-cell depletion in 2/21 pig-tails (vs. none in rhesus).
CONCLUSIONS: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
Authors:
Patricia Polacino; Kay Larsen; Lindsey Galmin; John Suschak; Zane Kraft; Leonidas Stamatatos; David Anderson; Susan W Barnett; Ranajit Pal; Kristen Bost; A H Bandivdekar; Christopher J Miller; Shiu-Lok Hu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of medical primatology     Volume:  37 Suppl 2     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-03-26     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
CD4-Positive T-Lymphocytes / immunology
Immunophenotyping / veterinary
Macaca mulatta*
Macaca nemestrina*
Simian Acquired Immunodeficiency Syndrome / virology*
Simian immunodeficiency virus / pathogenicity*
Species Specificity
Viremia / veterinary
Grant Support
ID/Acronym/Agency:
N01 AI060005/AI/NIAID NIH HHS; N01 AI060006/AI/NIAID NIH HHS; N01 AI30057/AI/NIAID NIH HHS; P01 AI05456/AI/NIAID NIH HHS; P01 AI054564/AI/NIAID NIH HHS; P01 AI054564-05/AI/NIAID NIH HHS; P01 AI066314/AI/NIAID NIH HHS; P51 RR0165/RR/NCRR NIH HHS; P51 RR0166/RR/NCRR NIH HHS; U 19 AI51596/AI/NIAID NIH HHS
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