| Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques. | |
| | |
MedLine Citation:
|
PMID: 19187427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases. METHODS: We compared the in vivo infectivity and pathogenicity of a CCR5-tropic SHIV(SF162 P4) after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4(+) T cell counts and clinical signs were monitored. RESULTS: Both rhesus and pig-tailed macaques are similarly susceptible to SHIV(SF162 P4) infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4(+) T-cell depletion in 2/21 pig-tails (vs. none in rhesus). CONCLUSIONS: Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species. |
| | |
Authors:
|
Patricia Polacino; Kay Larsen; Lindsey Galmin; John Suschak; Zane Kraft; Leonidas Stamatatos; David Anderson; Susan W Barnett; Ranajit Pal; Kristen Bost; A H Bandivdekar; Christopher J Miller; Shiu-Lok Hu |
Related Documents
:
|
7151327 - Properdin deficiency in a family with fulminant meningococcal infections. 4261837 - Polyserositis and arthritis due to escherichia coli in gnotobiotic pigs. 9011017 - Prevalence of cryptosporidium infections in pigs in aragón (northeastern spain). 12809937 - Inactivation of porcine endogenous retrovirus by human serum as a function of complemen... 11407677 - Medical management of benign oesophageal disease in patients with human immunodeficienc... 23639427 - Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differential... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of medical primatology Volume: 37 Suppl 2 ISSN: 0047-2565 ISO Abbreviation: J. Med. Primatol. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2009-02-03 Completed Date: 2009-03-26 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 13-23 Citation Subset: IM |
Affiliation:
|
Washington National Primate Research Center, University of Washington, Seattle, WA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals CD4-Positive T-Lymphocytes / immunology Immunophenotyping / veterinary Macaca mulatta* Macaca nemestrina* Simian Acquired Immunodeficiency Syndrome / virology* Simian immunodeficiency virus / pathogenicity* Species Specificity Viremia / veterinary |
| Grant Support | |
ID/Acronym/Agency:
|
N01 AI060005/AI/NIAID NIH HHS; N01 AI060006/AI/NIAID NIH HHS; N01 AI30057/AI/NIAID NIH HHS; P01 AI05456/AI/NIAID NIH HHS; P01 AI054564-05/AI/NIAID NIH HHS; P01 AI066314/AI/NIAID NIH HHS; P51 RR0165/RR/NCRR NIH HHS; P51 RR0166/RR/NCRR NIH HHS; U 19 AI51596/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: AIDS pathogenesis: a tale of two monkeys.
Next Document: Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs.