Document Detail

Differential orbicularis oculi involvement in neuromuscular junction dysfunction.
MedLine Citation:
PMID:  18791469     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Single-fiber electromyography is a sensitive electrophysiological method for the determination of neuromuscular dysfunction. Normative values for stimulated single-fiber electromyography have been reported for the orbicularis oculi (OOc) with no distinction made between the upper and lower OOc. The purpose of this study is to demonstrate that the upper and lower OOc differ in how they behave during dysfunction. METHODS: Patients in whom myasthenia gravis was suspected were included in the study. Strict selection criteria for single fiber potentials were used. RESULTS: Seventy-six patients were entered prospectively into this study. Twenty-six patients completed the study and obtained a final diagnosis. Twenty-one patients had abnormal stimulated single-fiber electromyography results. The lower OOc was found more likely to be abnormal based on the number of abnormal single fiber potentials (27.6% and 20.7% potentials from the lower and upper OOc, respectively). Both upper and lower OOc were abnormal in 13 patients and the lower OOc was solely abnormal in seven patients. The upper OOc was solely abnormal in two patients, neither of which had a diagnosis of myasthenia gravis. CONCLUSIONS: The lower OOc is an important muscle to examine, not only to rule out myasthenia gravis, but also to prevent the occurrence of false negative results.
Eleftherios S Papathanasiou; Eleni Zamba-Papanicolaou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  25     ISSN:  1537-1603     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-03     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Clinical Sciences, The Cyprus Institute of Neurology and Genetics, 6 International Airport Avenue, Nicosia 1683, Cyprus.
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MeSH Terms
Electromyography* / methods
Middle Aged
Neuromuscular Junction Diseases / diagnosis*
Oculomotor Muscles / physiopathology*

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