Document Detail

Differential nucleolus organizer activity in normal and leukemic bone marrow.
MedLine Citation:
PMID:  2464925     Owner:  NLM     Status:  MEDLINE    
A cytochemical technique that uses silver nitrate staining has been used to study the nucleolus organizer activity in bone marrow cells from 13 patients with acute lymphocytic leukemia (ALL), 11 patients with chronic myelogenous leukemia (CML), 7 patients with acute myelogenous leukemia (AML), and 4 healthy persons. Our results indicate that the nucleolus organizer region (NOR) activity was significantly lower in the control group than in the ALL patients. The NOR activity level was significantly lower in both the CML patients in chronic phase and the AML patients than in the ALL group and similar to the control group. These disease-related differences in NOR activity as detected by silver staining can be used as diagnostic procedure in evaluating human leukemias.
K C Arden; D A Johnston; A Cork; S Pathak
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  30     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-03-20     Completed Date:  1989-03-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-73     Citation Subset:  IM    
Department of Cell Biology, University of Texas M. D. Anderson Cancer Center 77030.
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MeSH Terms
Bone Marrow / physiopathology*,  ultrastructure
Leukemia / diagnosis,  genetics,  physiopathology*
Leukemia, Biphenotypic, Acute / diagnosis,  genetics,  physiopathology
Leukemia, Myeloid / diagnosis,  genetics,  physiopathology
Leukemia, Myeloid, Acute / diagnosis,  genetics,  physiopathology
Nucleolus Organizer Region / physiology*,  ultrastructure
Silver Nitrate / diagnostic use*
Staining and Labeling*
Reg. No./Substance:
7761-88-8/Silver Nitrate

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