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Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene.
MedLine Citation:
PMID:  21562671     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.
Authors:
Abhilash Sasidharan; L S Panchakarla; Parwathy Chandran; Deepthy Menon; Shantikumar Nair; C N R Rao; Manzoor Koyakutty
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-12
Journal Detail:
Title:  Nanoscale     Volume:  -     ISSN:  2040-3372     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, 682 041, Kerala, India. manzoork@aims.amrita.edu shantinair@aims.amrita.edu.
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