| Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. | |
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MedLine Citation:
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PMID: 15735744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurofibromatosis type 1 (NF1) is a common genetic disorder of the nervous system resulting in neurofibromas and malignant peripheral nerve sheath tumors (MPNST). In this study, we report the modulation of murine and human MPNST cell growth by the fatty acids docosahexaenoic acid (DHA) and arachidonic acid (AA). DHA demonstrated a tendency to stimulate cell growth at low doses and induce apoptosis at high doses, paralleled by the activation of ERK and caspase-3. Furthermore, high-dose DHA reversed the stimulation of MPNST cell growth by a number of growth factors suggested to have a pathogenic effect in NF1 and inhibited MPNST growth in vivo. AA was found to have a reciprocal activity in vitro, stimulating MPNST cell growth at comparable concentrations and reducing DHA activation of ERK. These findings introduce fatty acids as a possible regulator of MPNST development in NF1 patients. |
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Authors:
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George A Mashour; Stephanie N Drissel; Silke Frahm; Faris Farassati; Robert L Martuza; Victor-F Mautner; Andrea Kindler-Röhrborn; Andreas Kurtz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Oncogene Volume: 24 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-31 Completed Date: 2005-04-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 2367-74 Citation Subset: IM |
Affiliation:
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Molecular Neurosurgery Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Line DNA Primers Fatty Acids, Omega-3 / pharmacology* Fatty Acids, Omega-6 / pharmacology* Immunohistochemistry Mice Mitogen-Activated Protein Kinases / metabolism Nerve Sheath Neoplasms / enzymology, pathology* Phosphorylation Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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NS37895/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
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