Document Detail


Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells.
MedLine Citation:
PMID:  17341607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to examine the effect of low and high concentrations of H2O2 on cancer cell proliferation and apoptosis, and AMPK signaling pathways in HT-29 human colon cancer cells. Nontoxic doses of H2O2 (10 microM) induced cancer cell proliferation, whereas the toxic level of 1,000 microM H2O2 induced apoptosis. The stimulation of cell proliferation was accompanied with an increase in cyclooxygenase-2 (COX-2), and apoptosis induced by high-dose H2O2 was correlated with the activation of AMPK and negatively correlated with COX-2 expression. These results suggest that ROS at nontoxic levels can stimulate cancer cell growth by regulating AMP-activated protein kinase (AMPK) and/or COX-2, and the abundant exogenous ROS linked to the growth inhibition through modulating AMPK signaling pathways.
Authors:
In-Ja Park; Jin-Taek Hwang; Young Min Kim; Joohun Ha; Ock Jin Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1091     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-03-07     Completed Date:  2007-03-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-9     Citation Subset:  IM    
Affiliation:
Department of Food and Nutrition, Hannam University, 133 Ojeong-dong Daedeok-gu, Daejeon 306-791, Korea.
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases
Cell Proliferation* / drug effects
Colonic Neoplasms / enzymology*,  pathology*
HT29 Cells
Humans
Multienzyme Complexes / metabolism,  physiology*
Oxidative Stress / drug effects,  physiology
Protein-Serine-Threonine Kinases / metabolism,  physiology*
Reactive Oxygen Species / metabolism*,  pharmacology
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; 0/Reactive Oxygen Species; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases

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