Document Detail


Differential mechanical response and microstructural organization between non-human primate femoral and carotid arteries.
MedLine Citation:
PMID:  24532266     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Unique anatomic locations and physiologic functions predispose different arteries to varying mechanical responses and pathologies. However, the underlying causes of these mechanical differences are not well understood. The objective of this study was to first identify structural differences in the arterial matrix that would account for the mechanical differences between healthy femoral and carotid arteries and second to utilize these structural observations to perform a microstructurally motivated constitutive analysis. Femoral and carotid arteries were subjected to cylindrical biaxial loading and their microstructure was quantified using two-photon microscopy. The femoral arteries were found to be less compliant than the carotid arteries at physiologic loads, consistent with previous studies, despite similar extracellular compositions of collagen and elastin ([Formula: see text]). The femoral arteries exhibited significantly less circumferential dispersion of collagen fibers ([Formula: see text]), despite a similar mean fiber alignment direction as the carotid arteries. Elastin transmural distribution, in vivo axial stretch, and opening angles were also found to be distinctly different between the arteries. Lastly, we modeled the arteries' mechanical behaviors using a microstructural-based, distributed collagen fiber constitutive model. With this approach, the material parameters of the model were solved using the experimental microstructural observations. The findings of this study support an important role for microstructural organization in arterial stiffness.
Authors:
Ruoya Wang; Julia Raykin; Haiyan Li; Rudolph L Gleason; Luke P Brewster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-02-15
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  13     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-05     Completed Date:  -     Revised Date:  2014-12-05    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1041-51     Citation Subset:  IM; S    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
HL-070531/HL/NHLBI NIH HHS; K08 HL119592/HL/NHLBI NIH HHS; P51 OD011132/OD/NIH HHS; P51OD11132/OD/NIH HHS; P51RR165/RR/NCRR NIH HHS; ULITR000454//PHS HHS

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