Document Detail


Differential limb loading in miniature pigs (Sus scrofa domesticus): a test of chondral modeling theory.
MedLine Citation:
PMID:  22496283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variation in mechanical loading is known to influence chondrogenesis during joint formation. However, the interaction among chondrocyte behavior and variation in activity patterns is incompletely understood, hindering our knowledge of limb ontogeny and function. Here, the role of endurance exercise in the development of articular and physeal cartilage in the humeral head was examined in 14 miniature swine (Sus scrofa domesticus). One group was subjected to graded treadmill running over a period of 17 weeks. A matched sedentary group was confined to individual pens. Hematoxylin and eosin staining was performed for histomorphometry of cartilage zone thickness, chondrocyte count and cell area, with these parameters compared multivariately between exercised and sedentary groups. Comparisons were also made with femora from the same sample, focusing on humerus-femur differences between exercised and sedentary groups, within-cohort comparisons of humerus-femur responses and correlated changes within and across joints. This study shows conflicting support for the chondral modeling theory. The humeral articular cartilage of exercised pigs was thinner than that of sedentary pigs, but their physeal cartilage was thicker. While articular and physeal cartilage demonstrated between-cohort differences, humeral physeal cartilage exhibited load-induced responses of greater magnitude than humeral articular cartilage. Controlling for cohort, the humerus showed increased chondrocyte mitosis and cell area, presumably due to relatively greater loading than the femur. This represents the first known effort to evaluate chondral modeling across multiple joints from the same individuals. Our findings suggest the chondral response to elevated loading is complex, varying within and among joints. This has important implications for understanding joint biomechanics and development.
Authors:
Kimberly A Congdon; Ashley S Hammond; Matthew J Ravosa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  215     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-12     Completed Date:  2012-08-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1472-83     Citation Subset:  IM    
Affiliation:
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Cartilage, Articular / pathology*
Chondrocytes / pathology
Chondrogenesis
Extremities / physiology*
Femur / pathology
Growth Plate
Humerus / pathology
Male
Mitosis
Models, Anatomic
Models, Biological
Physical Conditioning, Animal
Stress, Mechanical
Sus scrofa
Weight-Bearing / physiology
Grant Support
ID/Acronym/Agency:
P01-HL52490/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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