Document Detail


Differential levels of circulating progenitor cells in acute coronary syndrome patients with a first event versus patients with recurring events.
MedLine Citation:
PMID:  20053471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Pathophysiology of acute coronary syndromes in patients presenting with a first cardiac event (FCE) can be different from patients with a recurring cardiac event (RCE). We assessed inflammatory activation and circulating progenitor cells' (CPC) mobilisation in patients with a FCE versus those with RCE.
METHODS: We recruited 41 patients: 18 with FCE and 23 with RCE. Peripheral blood samples were drawn at baseline and at 20 days to measure high sensitivity C-reactive protein (CRP) and to assess CD34+/133+ CPC and CD34+/KDR+ CPC by flow cytometry.
RESULTS: CD34+/133+ cells (% number of cells per total number of cytometric events) were similar at baseline, being 0.25% (0.17-0.42%) in the FCE vs 0.23% (0.11-0.43%) in the RCE group, and increased at follow-up only in the FCE group to 0.41% (0.22-0.64%), while in the RCE group they were 0.27% (0.11-0.36%) (p=0.009 for the interaction, p=0.07 for the main effect of time). CD34+/KDR+ cells were similar at baseline in the two groups, did not significantly increase over time (p=0.2), and no differential effect of FCE vs RCE over time was seen (p=0.38). CRP levels, similar at baseline, were consistently reduced at 20 days after ACS (p=0.001), with no differential effect of FCE vs RCE pts (p=0.74). Variation from baseline to follow-up for both CD34+/133+ and CD34+/KDR+ did not correlate with either baseline CRP or delta CRP.
CONCLUSIONS: Our data demonstrate a differential CPC mobilization behavior for FCE patients compared to RCE ones, independent of inflammatory activation.
Authors:
Italo Porto; Ilaria Dato; Luca Di Vito; Giovanni L De Maria; Alessandra Tritarelli; Antonio M Leone; Alessandra Paglia; Maurizio C Capogrossi; Luigi M Biasucci; Filippo Crea
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-01-06
Journal Detail:
Title:  International journal of cardiology     Volume:  149     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-13     Completed Date:  2011-09-15     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome* / blood,  drug therapy,  pathology
Aged
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antigens, CD / metabolism
Antigens, CD34 / metabolism
Benzimidazoles / therapeutic use*
Benzoates / therapeutic use*
C-Reactive Protein / metabolism
Female
Flow Cytometry
Glycoproteins / metabolism
Hematopoietic Stem Cells / cytology*,  metabolism
Humans
Linear Models
Male
Middle Aged
Peptides / metabolism
Prospective Studies
Ramipril / therapeutic use*
Recurrence
Chemical
Reg. No./Substance:
0/AC133 antigen; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antigens, CD; 0/Antigens, CD34; 0/Benzimidazoles; 0/Benzoates; 0/Glycoproteins; 0/Peptides; 9007-41-4/C-Reactive Protein; L35JN3I7SJ/Ramipril; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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