| Differential lectin reactivities of alpha-fetoprotein in hepatocellular carcinoma: diagnostic value when serum alpha-fetoprotein levels are slightly raised. | |
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MedLine Citation:
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PMID: 1377039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The specificity and sensitivity of alpha-fetoprotein (AFP) binding to Concanavalin-A (Con-A) and Lens culinaris agglutinin (LCA) in 26 South African blacks with advanced symptomatic hepatocellular carcinoma (HCC) but only slightly raised serum AFP concentrations (20-500 ng/mL) was compared with that in patients with similar serum AFP levels from diseases that might be mistaken clinically for HCC (seven 'benign' liver disease [BLD] patients and six with metastatic liver disease [MLD] from gastrointestinal tumours). Con-A-Sepharose-4B affinity chromatography did not differentiate between the different groups: fucosylation rations for the HCC patients were 0.81 +/- 0.60, compared with 0.63 +/- 0.27 and 0.54 +/- 0.32 in patients with BLD and MLD, respectively. Electrophoresis of AFP serum and fraction in the presence or absence of Con-A and LCA showed an increase in the AFP C2 band. Rank correlation analysis of the AFP L2 and L3 bands combined could distinguish between patients with HCC and other hepatic diseases (P less than 0.05). |
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Authors:
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L van Staden; S Bukofzer; M C Kew; N Savage |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 7 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 1992 May-Jun |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 260-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
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blood*,
diagnosis Chromatography, Affinity Concanavalin A / metabolism Diagnosis, Differential Humans Lectins / metabolism Liver Diseases / blood Liver Neoplasms / blood*, diagnosis Plant Lectins* Protein Binding Tumor Markers, Biological / blood* alpha-Fetoproteins / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 0/Plant Lectins; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins; 0/lentil lectin; 11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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