| Differential involvement of gustatory insular cortex and amygdala in the acquisition and retrieval of conditioned taste aversion in rats. | |
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MedLine Citation:
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PMID: 1335264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lesion studies of the role of the gustatory insular cortex (GC) and amygdala (Am) in conditioned taste aversion (CTA) are confounded by the irreversibility of the intervention. Functional ablation methods allow more specific influencing of different phases of CTA acquisition and retrieval. Bilateral tetrodotoxin (TTX) blockade of GC (10 ng) or Am (3 ng) before or after saccharin drinking in rats with chronically implanted intracerebral cannulae showed that GC is indispensable for the initial processing of the taste stimulus but not for the association of the gustatory trace with the symptoms of LiCl poisoning. Gustatory signals can by-pass the blocked Am, the inactivation of which, however, impairs the gustatory trace-poisoning association. TTX injection into both GC and Am impairs CTA retrieval more than isolated blockade of either of these structures. It is argued that GC and Am implement processing of gustatory and visceral signals, respectively, but that formation and consolidation of the CTA engram proceeds outside forebrain, probably at the level of the brainstem. |
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Authors:
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M Gallo; G Roldan; J Bures |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioural brain research Volume: 52 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-02-01 Completed Date: 1993-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Departamento de Psicologia Experimental y Fisiologia del Comportamiento, Universidad de Granada, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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physiology* Animals Association Learning / physiology Avoidance Learning / physiology* Cerebral Cortex / physiology* Chlorides / toxicity Conditioning, Classical / physiology* Lithium / toxicity Lithium Chloride Male Mental Recall / physiology* Rats Rats, Wistar Retention (Psychology) / physiology Taste / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 7439-93-2/Lithium; 7447-41-8/Lithium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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