Document Detail

Differential intraarterial pressure recordings from different arteries in the rat.
MedLine Citation:
PMID:  4021499     Owner:  NLM     Status:  MEDLINE    
Intraarterial pressures were recorded from five different sites in pentobarbital anesthetized rats. Simultaneous recordings were made from the brachial artery, carotid artery, femoral artery, tail artery, and a small end-branch of the superior mesenteric artery under basal conditions and under vasoconstrictor and vasodilator influences to find out whether similar mean arterial pressures (MAP) can be recorded from the various sites. It was found that MAP of proximal arteries (brachial and carotid) is higher than the MAP recorded from more distal arteries (mesenteric, tail, and femoral). A pressure difference of 5-6 mm Hg was found to exist from the level of the carotid artery to that of the femoral artery during all experimental conditions. Our results indicate that the same artery should always be used to compare MAP between different rats. Moreover, calculations of arterial resistance (MAP/BF) of most vascular beds in the rat, using MAP values obtained from the tail or the femoral artery, as are commonly done in physiologic or pharmacologic studies, can result in slightly lower resistance values than the true resistance. To obtain true arterial resistance of any vascular bed, one has to use MAP recorded at the particular vascular bed for the calculation of resistance.
C C Pang; T C Chan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacological methods     Volume:  13     ISSN:  0160-5402     ISO Abbreviation:  J Pharmacol Methods     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806596     Medline TA:  J Pharmacol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Blood Pressure Determination / methods*
Rats, Inbred Strains
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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