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Differential inhibition of polymorphonuclear leukocyte recruitment in vivo by dextran sulphate and fucoidan.
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MedLine Citation:
PMID:  18475729     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The selectin-mediated rolling of leukocytes along the endothelial cells is a prerequisite step followed by firm adhesion and extravasation into the inflamed tissue. This initial contact can be suppressed by sulphated polysaccharides. We have studied the effect of sulphated polysaccharides on the ultimate polymorphonuclear leukocyte (PMN) recruitment and plasma leakage in rabbit skin in response to intradermal injection of various inflammatory mediators. PMN infiltration evoked by various PMN chemoattractants (FMLP, C5a desArg, LTB(4) and IL-8) was significantly inhibited after intravenous injection of dextran sulphate (25 mg/kg), heparin (2 x 90 mg/kg) or fucoidan (1 mg/kg). PMN-dependent plasma leakage was equally well reduced by the different sulphated polymers. Vascular permeability induced by histamine or thrombin acting via a PMN-independent mechanism was not reduced. Fucoidan was the only polysaccharide able to suppress IL-1-induced PMN infiltration for 60-70%. Local administration of dextran sulphate had no effect on PMN-dependent plasma leakage. Differential inhibition of PMN recruitment was determined after injection of dextran sulphate or fucoidan depending on the type of insult. Therefore, these results suggest that different adhesion pathways are utilized during PMN recruitment in vivo in response to chemoattractants and IL-1.
Authors:
N V Osselaer; M Rampart; A G Herman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  5     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1996  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-57     Citation Subset:  -    
Affiliation:
Division of Pharmacology Faculty of Medicine University of Antwerp (UIA) Universiteitsplein 1 Wilrijk B-2610 Belgium.
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Full Text
Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
ISSN: 1466-1861
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 1996 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Month: 10 Year: 1996
Volume: 5 Issue: 5
First Page: 346 Last Page: 357
ID: 2365801
PubMed Id: 18475729
Publisher Item Identifier: S0962935196000506
DOI: 10.1155/S0962935196000506

Differential inhibition of polymorphonuclear leukocyte recruitment in vivo by dextran sulphate and fucoidan
N. Van Osselaer
M. Rampart
A. G. Herman
1Division of PharmacologyFaculty of MedicineUniversity of Antwerp (UIA)Universiteitsplein 1WilrijkB-2610Belgium


Article Categories:
  • Research Article


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