Document Detail

Differential inhibition of polymorphonuclear leukocyte recruitment in vivo by dextran sulphate and fucoidan.
Jump to Full Text
MedLine Citation:
PMID:  18475729     Owner:  NLM     Status:  In-Data-Review    
The selectin-mediated rolling of leukocytes along the endothelial cells is a prerequisite step followed by firm adhesion and extravasation into the inflamed tissue. This initial contact can be suppressed by sulphated polysaccharides. We have studied the effect of sulphated polysaccharides on the ultimate polymorphonuclear leukocyte (PMN) recruitment and plasma leakage in rabbit skin in response to intradermal injection of various inflammatory mediators. PMN infiltration evoked by various PMN chemoattractants (FMLP, C5a desArg, LTB(4) and IL-8) was significantly inhibited after intravenous injection of dextran sulphate (25 mg/kg), heparin (2 x 90 mg/kg) or fucoidan (1 mg/kg). PMN-dependent plasma leakage was equally well reduced by the different sulphated polymers. Vascular permeability induced by histamine or thrombin acting via a PMN-independent mechanism was not reduced. Fucoidan was the only polysaccharide able to suppress IL-1-induced PMN infiltration for 60-70%. Local administration of dextran sulphate had no effect on PMN-dependent plasma leakage. Differential inhibition of PMN recruitment was determined after injection of dextran sulphate or fucoidan depending on the type of insult. Therefore, these results suggest that different adhesion pathways are utilized during PMN recruitment in vivo in response to chemoattractants and IL-1.
N V Osselaer; M Rampart; A G Herman
Related Documents :
1592489 - Mechanisms of endothelial cell-dependent leukocyte adhesion stimulated by platelet-acti...
8978289 - Platelet and fibrin deposition at the damaged vessel wall: cooperative substrates for n...
16439099 - Differential progression of neonatal diethylstilbestrol-induced disruption of the hamst...
8092009 - Felix fleischner lecture. the traffic of polymorphonuclear leukocytes through pulmonary...
7901109 - Mechanisms involved in helicobacter pylori-induced inflammation.
18664529 - Expression of sialyltransferase activity on intact human neutrophils.
23104739 - Leukocyte migration from a fish eye's view.
16033269 - Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as no...
16125129 - A new method of biosensing with 1 microl of escherichia coli suspension using atomic fo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  5     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1996  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-57     Citation Subset:  -    
Division of Pharmacology Faculty of Medicine University of Antwerp (UIA) Universiteitsplein 1 Wilrijk B-2610 Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
ISSN: 1466-1861
Publisher: Hindawi Publishing Corporation
Article Information
Download PDF
Copyright © 1996 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Month: 10 Year: 1996
Volume: 5 Issue: 5
First Page: 346 Last Page: 357
ID: 2365801
PubMed Id: 18475729
Publisher Item Identifier: S0962935196000506
DOI: 10.1155/S0962935196000506

Differential inhibition of polymorphonuclear leukocyte recruitment in vivo by dextran sulphate and fucoidan
N. Van Osselaer
M. Rampart
A. G. Herman
1Division of PharmacologyFaculty of MedicineUniversity of Antwerp (UIA)Universiteitsplein 1WilrijkB-2610Belgium

Article Categories:
  • Research Article

Previous Document:  Degranulation of rat omental mast cells by A(1) receptor agonists in vitro.
Next Document:  Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal...